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Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana

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dc.contributor.authorSuksamrarn S.
dc.contributor.authorPanseeta P.
dc.contributor.authorKunchanawatta S.
dc.contributor.authorDistaporn T.
dc.contributor.authorRuktasing S.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:32:22Z
dc.date.available2021-04-05T04:32:22Z
dc.date.issued2006
dc.date.issuedBE2549
dc.description.abstractOne new and eight known ceanothane- and lupane-type triterpenes were isolated from the root bark of Ziziphus cambodiana PIERRE (Rhamnaceae). Based on spectral analyses, the structure of the new compound was elucidated as 3-O-(4-hydroxy-3-methoxybenzoyl)ceanothic acid (3-O-vanillylceanothic acid) (1), while the known compounds were identified as lupeol (2), betulinaldehyde (3), betulinic acid (4), 2-O-E-p-coumaroyl alphitolic acid (5), alphitolic acid (6), zizyberanalic acid (7), zizyberenalic acid (8) and ceanothic acid (9). Compounds 1, 5 and 8 exhibited significant in vitro antiplasmodial activity against the parasite Plasmodium falciparum, with inhibitory concentration (IC50) values of 3.7, 0.9 and 3.0 μg/ml, respectively. Compounds 1 and 3-8 showed antimycobacterial activity against Mycobacterium tuberculosis with respective MIC values of 25, 25, 25, 12.5, 50, 50 and 100 μg/ml. © 2006 Pharmaceutical Society of Japan.
dc.format.mimetypeapplication/pdf
dc.identifier.citationChemical and Pharmaceutical Bulletin. Vol 54, No.4 (2006), p.535-537
dc.identifier.doi10.1248/cpb.54.535
dc.identifier.issn92363
dc.identifier.other2-s2.0-33645554565
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5858
dc.rights.holderScopus
dc.subject.other2 o 4 coumaroyl alphitolic acid
dc.subject.other3 o (4 hydroxy 3 methoxybenzoyl)ceanothic acid (3 o vanillylceanothic acid
dc.subject.otherAlphitolic acid
dc.subject.otherBetulic acid
dc.subject.otherBetulinaldehyde
dc.subject.otherCeanothic acid
dc.subject.otherLupeol
dc.subject.otherPlant extract
dc.subject.otherTriterpene derivative
dc.subject.otherUnclassified drug
dc.subject.otherZiziphus cambodiana extract
dc.subject.otherZizyberanalic acid
dc.subject.otherZizyberenalic acid
dc.subject.otherAntibacterial activity
dc.subject.otherAntimalarial activity
dc.subject.otherArticle
dc.subject.otherDrug isolation
dc.subject.otherDrug structure
dc.subject.otherHuman
dc.subject.otherIC 50
dc.subject.otherJujube
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherNonhuman
dc.subject.otherPlasmodium falciparum
dc.subject.otherSpectroscopy
dc.subject.otherAnimals
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherAntimalarials
dc.subject.otherCeanothus
dc.subject.otherInhibitory Concentration 50
dc.subject.otherMicrobial Sensitivity Tests
dc.subject.otherMolecular Structure
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherPlant Roots
dc.subject.otherPlasmodium falciparum
dc.subject.otherTriterpenes
dc.subject.otherZiziphus
dc.titleCeanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33645554565&doi=10.1248%2fcpb.54.535&partnerID=40&md5=a7c291ff6ac84137bd0f0759fe9df414

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