Publication:
Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana

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Issued Date

2006

Resource Type

Article

File Type

application/pdf

ISSN

92363

DOI

10.1248/cpb.54.535

Other identifier(s)

2-s2.0-33645554565

Rights Holder(s)

Scopus

Bibliographic Citation

Chemical and Pharmaceutical Bulletin. Vol 54, No.4 (2006), p.535-537

Suggested Citation

Suksamrarn S., Panseeta P., Kunchanawatta S., Distaporn T., Ruktasing S., Suksamrarn A. Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana. Chemical and Pharmaceutical Bulletin. Vol 54, No.4 (2006), p.535-537. doi:10.1248/cpb.54.535 Retrieved from: https://hdl.handle.net/20.500.14740/5858

Title

Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana

Author(s)

Suksamrarn S.
 Panseeta P.
 Kunchanawatta S.
 Distaporn T.
 Ruktasing S.
 Suksamrarn A.

Abstract

One new and eight known ceanothane- and lupane-type triterpenes were isolated from the root bark of Ziziphus cambodiana PIERRE (Rhamnaceae). Based on spectral analyses, the structure of the new compound was elucidated as 3-O-(4-hydroxy-3-methoxybenzoyl)ceanothic acid (3-O-vanillylceanothic acid) (1), while the known compounds were identified as lupeol (2), betulinaldehyde (3), betulinic acid (4), 2-O-E-p-coumaroyl alphitolic acid (5), alphitolic acid (6), zizyberanalic acid (7), zizyberenalic acid (8) and ceanothic acid (9). Compounds 1, 5 and 8 exhibited significant in vitro antiplasmodial activity against the parasite Plasmodium falciparum, with inhibitory concentration (IC50) values of 3.7, 0.9 and 3.0 μg/ml, respectively. Compounds 1 and 3-8 showed antimycobacterial activity against Mycobacterium tuberculosis with respective MIC values of 25, 25, 25, 12.5, 50, 50 and 100 μg/ml. © 2006 Pharmaceutical Society of Japan.

Subject(s)

2 o 4 coumaroyl alphitolic acid
 3 o (4 hydroxy 3 methoxybenzoyl)ceanothic acid (3 o vanillylceanothic acid
 Alphitolic acid
 Betulic acid
 Betulinaldehyde
 Ceanothic acid
 Lupeol
 Plant extract
 Triterpene derivative
 Unclassified drug
 Ziziphus cambodiana extract
 Zizyberanalic acid
 Zizyberenalic acid
 Antibacterial activity
 Antimalarial activity
 Article
 Drug isolation
 Drug structure
 Human
 IC 50
 Jujube
 Minimum inhibitory concentration
 Mycobacterium tuberculosis
 Nonhuman
 Plasmodium falciparum
 Spectroscopy
 Animals
 Anti-Bacterial Agents
 Antimalarials
 Ceanothus
 Inhibitory Concentration 50
 Microbial Sensitivity Tests
 Molecular Structure
 Mycobacterium tuberculosis
 Plant Roots
 Plasmodium falciparum
 Triterpenes
 Ziziphus

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URI

https://hdl.handle.net/20.500.14740/5858

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Scopus: Year 1983-2021

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