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A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity

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dc.contributor.authorPrachayasittikul S.
dc.contributor.authorPingaew R.
dc.contributor.authorWorachartcheewan A.
dc.contributor.authorRuchirawat S.
dc.contributor.authorPrachayasittikul V.
dc.date.accessioned2021-04-05T03:35:59Z
dc.date.available2021-04-05T03:35:59Z
dc.date.issued2010
dc.date.issuedBE2553
dc.description.abstractBioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.
dc.format.mimetypeapplication/pdf
dc.identifier.citationEXCLI Journal. Vol 9, No. (2010), p.102-107
dc.identifier.issn16112156
dc.identifier.other2-s2.0-79151486711
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7451
dc.rights.holderScopus
dc.subject.other1,2,3,6 tetrahydro 4 phenylpyridine
dc.subject.otherN acetyl 2(1 adamantylsulfoxo) 3 acetoxy 4 phenyl 6 hydroxy 1,2,3,6 tetrahydropyridine
dc.subject.otherSulfoxide
dc.subject.otherUnclassified drug
dc.subject.otherAntimicrobial activity
dc.subject.otherArticle
dc.subject.otherControlled study
dc.subject.otherDrug structure
dc.subject.otherDrug synthesis
dc.subject.otherHuman
dc.subject.otherInfrared radiation
dc.subject.otherMass spectrometry
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherMoraxella catarrhalis
dc.subject.otherNonhuman
dc.subject.otherNuclear magnetic resonance
dc.subject.otherStreptococcus pyogenes
dc.subject.otherThin layer chromatography
dc.subject.otherUltraviolet radiation
dc.subject.otherMoraxella catarrhalis
dc.subject.otherStreptococcus pyogenes
dc.titleA new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79151486711&partnerID=40&md5=fd263d24f05e311169737354b58b6085

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