Publication:
A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

16112156

Other identifier(s)

2-s2.0-79151486711

Rights Holder(s)

Scopus

Bibliographic Citation

EXCLI Journal. Vol 9, No. (2010), p.102-107

Suggested Citation

Prachayasittikul S., Pingaew R., Worachartcheewan A., Ruchirawat S., Prachayasittikul V. A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity. EXCLI Journal. Vol 9, No. (2010), p.102-107. Retrieved from: https://hdl.handle.net/20.500.14740/7451

Title

A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity

Author(s)

Prachayasittikul S.
 Pingaew R.
 Worachartcheewan A.
 Ruchirawat S.
 Prachayasittikul V.

Abstract

Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.

Subject(s)

1,2,3,6 tetrahydro 4 phenylpyridine
 N acetyl 2(1 adamantylsulfoxo) 3 acetoxy 4 phenyl 6 hydroxy 1,2,3,6 tetrahydropyridine
 Sulfoxide
 Unclassified drug
 Antimicrobial activity
 Article
 Controlled study
 Drug structure
 Drug synthesis
 Human
 Infrared radiation
 Mass spectrometry
 Minimum inhibitory concentration
 Moraxella catarrhalis
 Nonhuman
 Nuclear magnetic resonance
 Streptococcus pyogenes
 Thin layer chromatography
 Ultraviolet radiation
 Moraxella catarrhalis
 Streptococcus pyogenes

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URI

https://hdl.handle.net/20.500.14740/7451

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Scopus: Year 1983-2021

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