Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29547
ชื่อเรื่อง: Porous Swellable Hypromellose Composite Fortified with Eucalyptus camaldulensis Leaf Hydrophobic/Hydrophilic Phenolic-rich Extract to Mitigate Dermal Wound Infections
ผู้แต่ง: Chidrawar V.R.
Singh S.
Jayeoye T.J.
Dodiya R.
Samee W.
Chittasupho C.
Keywords: Anti-inflammatory
Antibacterial
Antioxidant
Eucalyptus camaldulensis
Hemostasis
Hypromellose composite
วันที่เผยแพร่: 2023
สำนักพิมพ์: Springer
บทคัดย่อ: Contagious wound infection has become one of the most common challenges concomitants with the wounds, causing severe inflammatory responses, and ultimately delaying skin tissue regeneration. Herein, a phenolic-rich Eucalyptus camaldulensis leaf hydrophobic (ECG) and hydrophilic extract (ECY), in varied content was fortified within a hypromellose polymeric matrix was characterized, and further targeted as an effective antioxidative, antimicrobial, anti-inflammatory, and hemostasis dressing. Infrared spectroscopy and thermal analysis of ECG and ECY fortified composite indicated significant hydrogen bonding-based cross-linking, while scanning electron microscopy image showed a porous structure. The chromatography profiling demonstrated 0.022 ± 0.02 and 0.027 ± 0.01 µg/mg of quercetin for the ECG and ECY fortified composite, respectively. The antibacterial and antioxidant activity of extract incorporated composite was significantly (p < 0.001) higher than that of control. Biocompatibility results revealed that composites were compatible with > 80% viability of HaCaT and RAW 264.7 cells. The results of the blood-coagulation and clotting kinetics showed time and dose-dependent hemostasis. Eucalyptus camaldulensis leaf hydrophilic extract incorporated composite significantly (p < 0.001) attenuated the nitrite production against lipopolysaccharides-stimulated macrophage cells. Moreover, the HaCaT cell showed migration of 43.59 ± 1.26 (%) and 48.12 ± 1.85 (%) treated with ECG and ECY incorporated composite after 24 h, respectively. Overall, the hydrophilic extract-incorporated composites showed multifarious biological properties, suggesting their potential for comprehensive wound healing dressing. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85152786709&doi=10.1007%2fs10924-023-02860-8&partnerID=40&md5=9ad861e1870ba1c16cdaa2730ed89c59
https://ir.swu.ac.th/jspui/handle/123456789/29547
Appears in Collections:Scopus 2023

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