Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29372
ชื่อเรื่อง: Endothelial activation and stress index as a prognostic factor of diffuse large B-cell lymphoma: the report from the nationwide multi-center Thai Lymphoma Study Group
ผู้แต่ง: Thanhakun R.
Wudhikarn K.
Bunworasate U.
Rattanathammethee T.
Norasetthada L.
Kanya P.
Chaloemwong J.
Wongkhantee S.
Phiphitaporn P.
Chansung K.
Jit-ueakul D.
Laoruangroj C.
Prayongratana K.
Wong P.
Julamanee J.
Lekhakula A.
Chuncharunee S.
Niparuck P.
Kanitsap N.
Makruasi N.
Suwanban T.
Praditsuktavorn P.
Khuhapinant A.
Intragumtornchai T.
Keywords: Diffuse large B-cell lymphoma
EASIX
Endothelial activation and stress index
Outcomes
Prognosis
วันที่เผยแพร่: 2023
สำนักพิมพ์: Springer Science and Business Media Deutschland GmbH
บทคัดย่อ: Several prognostic models have been introduced to predict outcomes of patients with diffuse large B-cell lymphoma (DLBCL). Endothelial activation and stress index (EASIX) is a surrogate of endothelial dysfunction which has been shown to predict outcomes of patients with various hematologic malignancies. However, the prognostic implication of EASIX for DLBCL is limited and warrants exploration. We conducted a retrospective study enrolling adult DLBCL patients including a discovery cohort from the single-centered university hospital database and a validation cohort from the independent nationwide multi-center registry. EASIX scores were calculated using creatinine, lactate dehydrogenase, and platelet levels. The receiver operating characteristic curve analysis was used to determine optimal cutoff. Statistical analysis explored the impact of EASIX on survival outcomes. A total of 323 patients were included in the discovery cohort. The optimal EASIX cutoff was 1.07 stratifying patients into low (53.9%) and high EASIX (46.1%) groups. Patients with high EASIX had worse 2-year progression-free survival (PFS) (53.4% vs. 81.5%, p<0.001) and overall survival (OS) (64.4% vs. 88.7%, p<0.001) than patients with low EASIX. Multivariate analysis revealed that older age, bulky disease, impaired performance status, and high EASIX were associated with an unfavorable OS. In the validation cohort of 499 patients, the optimal EASIX cutoff was 1.04. Similar to the discovery cohort, high EASIX score was associated with high-risk diseases, worse PFS, and inferior OS. In conclusion, EASIX score was significantly associated with survival outcomes and may be used as a simple prognostic tool to better risk-classify DLBCL. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171307501&doi=10.1007%2fs00277-023-05437-6&partnerID=40&md5=bdcd9f7c3a9427781dd8a3cb7b3a4596
https://ir.swu.ac.th/jspui/handle/123456789/29372
Appears in Collections:Scopus 2023

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