Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29203
ชื่อเรื่อง: Beneficial Effects of Indigenous Probiotics in High-Cholesterol Diet-Induced Hypercholesterolemic Rats
ผู้แต่ง: Puttarat N.
Kasorn A.
Vitheejongjaroen P.
Chantarangkul C.
Tangwattanachuleeporn M.
Taweechotipatr M.
Keywords: bile salt hydrolase
cholesterol-lowering activity
hypercholesterolemia
microbiota
probiotics
วันที่เผยแพร่: 2023
สำนักพิมพ์: Multidisciplinary Digital Publishing Institute (MDPI)
บทคัดย่อ: Hypercholesterolemia is a significant risk factor for cardiovascular disease and metabolic disorders. Probiotics are the essential constituents of the gastrointestinal microbiota that provide health-promoting effects. Cholesterol-lowering activity is a specific property of probiotics, improving the cholesterol metabolism without adverse effects. Thus, the purpose of this study was to investigate the hypocholesterolemic effect of single and mixed cholesterol-lowering probiotic strains (including Limosilactobacillus reuteri TF-7, Enterococcus faecium TF-18, and Bifidobacterium animalis TA-1) in high-cholesterol diet (HCD)-induced hypercholesterolemic rats. The results showed that the administration of single probiotics contributed to a reduction in the body weight gain, visceral organ indexes, hyperlipidemia, and hepatic steatosis and also an improvement in the gastrointestinal microbiota. Besides the effect of single cholesterol-lowering probiotics, three probiotics strains could also synergize their hypocholesterolemic effect when administered simultaneously. These findings indicate that three cholesterol-lowering probiotic strains are suitable for development as probiotic supplements to reduce the risk of diseases caused by cholesterol and exert health benefits with synergistic effect when administered simultaneously. © 2023 by the authors.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164036997&doi=10.3390%2fnu15122710&partnerID=40&md5=31d2bac3960698d938f0c047eb361ae6
https://ir.swu.ac.th/jspui/handle/123456789/29203
Appears in Collections:Scopus 2023

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