Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/29151
ชื่อเรื่อง: Effect of Magnesium Chloride in Supporting Electrolyte for Enhancing Sensitive and Selective Electrochemical Sensor: An Approach for Anti-Rheumatic Sulfasalazine Detection
ผู้แต่ง: Promvichai S.
Kaewjua K.
Meoipun A.
Chotsuwan C.
Chailapakul O.
Siangproh W.
Keywords: Drug
Electrolyte Components
Screen-Printed Graphene Electrode
Serum
Sulfasalazine
Urine
วันที่เผยแพร่: 2023
สำนักพิมพ์: Institute of Physics
บทคัดย่อ: In this work, an electroanalytical evaluation for voltammetric sensing of the anti-rheumatic sulfasalazine (SSZ) at an unmodified screen-printed graphene electrode (SPGE) is demonstrated. By using the differential pulse (DPV) technique, the SSZ produced a well-defined peak of around -0.3 V (vs Ag AgCl-1) in Britton-Robinson (BR) buffer pH 4. Supporting electrolytes, pH, and salts all significantly impact SSZ reduction. Therefore, their impact on the working solutions was assessed. We discovered that using a mixture of Britton-Robinson (BR) buffer with pH 4 and MgCl2 as a supporting electrolyte can enhance SSZ sensitivity by approximately 1.7 times while simultaneously increasing detection selectivity. Under optimal conditions, the proposed assay demonstrated the ultrasensitive determination of SSZ with a broad linear detection range from 0.01 to 100 μM and a low detection limit of 4.7 nM (S/N = 3). To demonstrate the impact of the proposed method, the sensor has been successfully applied for the quantitative determination of SSZ in pharmaceutical, urine, and artificial serum sample. Therefore, this approach could offer simplicity, and rapidity, and serve as an alternative to the SSZ detection in practical applications. © 2023 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163409830&doi=10.1149%2f1945-7111%2facd725&partnerID=40&md5=6edbc6e63feb6de56fdf24ede3e1ee8c
https://ir.swu.ac.th/jspui/handle/123456789/29151
Appears in Collections:Scopus 2023

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.