Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27271
ชื่อเรื่อง: Minimum Contact Time of 1.25%, 2.5%, 5%, and 10% Benzoyl Peroxide for a Bactericidal Effect Against Cutibacterium acnes
ผู้แต่ง: Boonchaya P.
Rojhirunsakool S.
Kamanamool N.
Khunkhet S.
Yooyongsatit S.
Udompataikul M.
Taweechotipatr M.
Keywords: Acne
C. acnes
Cleanser
P. acnes
Short contact therapy
Time killing
วันที่เผยแพร่: 2022
สำนักพิมพ์: Dove Medical Press Ltd
บทคัดย่อ: Purpose: Benzoyl peroxide (BPO) is an effective acne treatment and has been used as a cleanser and short contact therapy. However, data on the minimum contact time of BPO needed to kill Cutibacterium acnes are lacking. Thus, the aim of this study was to determine the minimum contact time of commonly used BPO concentrations for bactericidal effects on C. acnes. Materials and Methods: An in vitro experimental study of clinically isolated C. acnes was performed to determine the minimal inhibitory concentration (MIC) of BPO using the broth microdilution method. Subsequently, the minimum contact times of various concentrations of BPO were evaluated, and their bactericidal effects were assessed by the plate count method. Results: The median MIC of BPO was 9375 µg/mL, which did not significantly differ between antibiotic-resistant and nonresistant C. acnes. The minimum contact time of BPO with C. acnes was significantly different among the BPO concentrations. For bactericidal activity against all isolates, 1.25%, 2.5%, 5%, and 10% BPO required 60 min, 15 min, 30 sec, and 30 sec, respectively. Conclusion: BPO demonstrated bactericidal activity against both antibiotic-resistant and antibiotic-susceptible C. acnes. The in vitro contact time needed to kill C. acnes was almost immediate with 5% or more BPO, but ≤ 2.5% BPO required longer contact times for bactericidal effects. © 2022 Boonchaya et al.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126823016&doi=10.2147%2fCCID.S359055&partnerID=40&md5=bd504d8b1bff405edb3a39a6e56ec4d6
https://ir.swu.ac.th/jspui/handle/123456789/27271
ISSN: 11787015
Appears in Collections:Scopus 2022

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