Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27234
ชื่อเรื่อง: Increased Salivary Periodontal Pathogens and IL-17A in Oral Lichen Planus Patients with or without Periodontitis
ผู้แต่ง: Talungchit S.
Buajeeb W.
Khovidhunkit S.-O.P.
Surarit R.
Chairatvit K.
Roytrakul S.
Kobayashi H.
Izumi Y.
Keywords: Oral lichen planus
Periodontal pathogens
Periodontitis
Salivary IL-17A
วันที่เผยแพร่: 2022
สำนักพิมพ์: Jaypee Brothers Medical Publishers (P) Ltd
บทคัดย่อ: Aim: Patients with oral lichen planus (OLP) who have gingival involvement are at increased risk for periodontal disease. This study aimed to investigate salivary levels of periodontopathic bacteria and inflammatory cytokines in OLP patients with or without periodontitis. Materials and methods: Seventeen OLP patients and 20 control subjects were evaluated for their Periodontal Screening and Recording (PSR) score to classify if they had periodontitis. Four groups were studied, OLP patients with periodontitis (OLP-P), without periodontitis (OLP), periodontitis patients (P) and normal subjects (N). Salivary levels of Aggregatibacter actinomycetemcomitans (Aa), Fusobacterium nucleatum (Fn), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Treponema denticola (Td), and Tannerella forsythia (Tf) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Salivary levels of interleukin (IL)-1β, IL-6, and IL-17A were measured by enzyme-linked immunosorbent assay (ELISA). Results: OLP-P and P groups had higher plaque index, bleeding on probing, and PSR scores than other groups. OLP-P and OLP patients had increased salivary Aa, Fn, Pi, Td, Tf with significantly high levels of Pi as well as high salivary IL-1β, IL-6, and IL-17A. IL-17A levels were significantly highest in the OLP-P group. Salivary IL-1β was significantly correlated with the level of Pi. Conclusion: OLP patients with or without periodontitis had high levels of salivary periodontal pathogens and IL-17A. Clinical significance: These data supported that OLP patients were at high risk for periodontitis. Oral hygiene maintenance in OLP patients with gingival lesions is of importance and could help prevent periodontitis. © The Author(s).
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128810076&doi=10.5005%2fjp-journals-10015-2049&partnerID=40&md5=dd79dee21ac1b35719f15a9c94648c0b
https://ir.swu.ac.th/jspui/handle/123456789/27234
ISSN: 9766006
Appears in Collections:Scopus 2022

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