Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27184
ชื่อเรื่อง: Factors predicting postoperative morbidity after cytoreductive surgery for ovarian cancer: a systematic review and meta-analysis
ผู้แต่ง: Kengsakul M.
Nieuwenhuyzen-De Boer G.M.
Udomkarnjananun S.
Kerr S.J.
Niehot C.D.
van Beekhuizen H.J.
Keywords: Albumin
Complication
Cytoreductive Surgery
Morbidity
Mortality
Ovarian Cancer
วันที่เผยแพร่: 2022
สำนักพิมพ์: Korean Society of Gynecologic Oncology and Colposcopy
บทคัดย่อ: Objective: Advances in ovarian cancer cytoreductive surgery have enabled more extensive procedures to achieve maximal cytoreduction but with a consequent increase in postoperative morbidity and mortality. The aim of this study was to evaluate factors for postoperative morbidity after extensive cytoreductive surgery for primary epithelial ovarian cancer (EOC), particularly those which may be modifiable. Methods: Electronic databases were searched. Meta-analysis was conducted using random-effects models. Results: Fifteen relevant studies, involving 15,325 ovarian cancer patients, were included in this review. Severe 30-day postoperative complications occurred in 2,357 (15.4%) patients. The postoperative mortality rate was 1.92%. Meta-analysis demonstrated that patient with following risk factors; age (p<0.001), Eastern Cooperative Oncology Group score >0 (p=0.001), albumin level <3.5 g/dL (p<0.001), presence of ascites on CT scan (p=0.013), stage IV disease (p<0.001) and extensive surgical procedure (p<0.001) has a significantly increase risk of developing postoperative complications. Surgical procedures including peritonectomy (p=0.012), splenectomy (p<0.001) and colon surgery (p<0.001) were significant predictors for postoperative complications. Moreover, we found that patients who received neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) had a lower risk of developing severe complications compared to those who underwent primary debulking surgery (PDS) (p<0.001). Conclusion: Our study demonstrated that patient performance status and hypoalbuminemia were the only significant adjustable preoperative risk factors associated with postoperative complications. Patients who underwent NACT-IDS had a lower risk of developing severe complications compared to PDS. Trial Registration: International Prospective Register of Systematic Reviews (PROSPERO) Identifier: CRD42021282770. © 2022. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133446365&doi=10.3802%2fjgo.2022.33.e53&partnerID=40&md5=663431dd8b1540c52f4b4959bd4f5dc9
https://ir.swu.ac.th/jspui/handle/123456789/27184
ISSN: 20050380
Appears in Collections:Scopus 2022

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