Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27167
ชื่อเรื่อง: Enhancing Anticancer Potency of a 13-Substituted Berberine Derivative with Cationic Liposomes
ผู้แต่ง: Apiratikul N.
Sriklung K.
Dolsophon K.
Thamvapee P.
Watanapokasin R.
Yingyongnarongkul B.-E.
Niyomtham N.
Bremner J.B.
Watanavetch P.
Samosorn S.
Keywords: cancer
cationic lipid
encapsulation
Key words berberine derivative
telomere
วันที่เผยแพร่: 2022
สำนักพิมพ์: Pharmaceutical Society of Japan
บทคัดย่อ: Cationic liposomal formulations of the telomeric G-quadruplex stabilizing ligand, 13-(2-naphthylmethoxy)-berberine bromide (1), have been developed with the purpose of delivering 1 into the nucleus of cancer cells for potential telomere targeting. Berberine derivative 1 was encapsulated in various cationic lipids 2–4 by the thin film evaporation method; these lipids are cationic after amine protonation. The most appropriate liposomal berberine formulation was that of 1 and the cholesterol derived cationic lipid 4 in a weight ratio of 1:20 with 76.5% encapsulation efficiency of 1. Cellular uptake studies in the HeLa and HT-29 cancer cells lines showed that the liposomal berberine derivative uptake in the cells was higher and more stable than for berberine derivative 1 alone while free 1 was completely decomposed in the cells within 60min exposure to the cells. Anticancer activity of the liposomal berberine derivative 1 based on 4 was greater than that for the free berberine derivative 1 in the MCF-7, HeLa and HT-29 cell line by 2.3-, 4.9- and 5.3-fold, respectively, and also, interestingly, superior to the anticancer drug doxorubicin against the HT29 cancer cell line. © 2022 The Pharmaceutical Society of Japan
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131269437&doi=10.1248%2fcpb.c21-01049&partnerID=40&md5=138365c83e46abdffe4f32cb6ed74e63
https://ir.swu.ac.th/jspui/handle/123456789/27167
ISSN: 92363
Appears in Collections:Scopus 2022

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