Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17528
ชื่อเรื่อง: Thunbergia laurifolia linn. Extract protects ethanol addiction and increases dopamine synthesis
ผู้แต่ง: Sangpayap R.
Pramong R.
Phansuwan-Pujito P.
Thongsaard W.
Keywords: alcohol
plant extract
Thunbergia laurifolia extract
tyrosine 3 monooxygenase
unclassified drug
addiction
adult
alcohol intoxication
animal experiment
animal model
animal tissue
anxiety
Article
behavior change
conditioned place preference test
controlled study
detoxification
dopamine metabolism
dopaminergic system
exploratory behavior
immunohistochemistry
liquid chromatography-mass spectrometry
male
medicinal plant
mesolimbic dopaminergic system
nonhuman
nucleus accumbens
protein expression
rat
reward
Thunbergia laurifolia
traditional medicine
Wistar rat
วันที่เผยแพร่: 2021
บทคัดย่อ: Thunbergia laurifolia Linn. is a plant used in traditional medicine for the detoxification of several substances including ethanol. Previous studies showed that T. laurifolia increased neuronal activity and altered the dopaminergic system in various brain areas similar to the effect of amphetamine and cocaine, but did not produce addiction in a chronic study. In the present study, we investigated the protective effect of T. laurifolia on behavioural changes and alteration of the tyrosine hydroxylase expressions in the mesolimbic dopaminergic pathway in acute and chronic ethanol administration in adult male Wistar rats. The animals were divided into four groups i.e., control, ethanol, T. laurifolia (200 mg/kg, i.p.), and T. laurifolia (200 mg/kg, i.p.) with ethanol in both acute and chronic (30 days) administrations. The anxiety behaviour, exploratory behaviour, and addiction behaviour were tested and tyrosine hydroxylase expression alteration was determined. Chronic ethanol administration significantly (p < 0.01) induced addictive behaviour in the conditioned place preference (CPP) test and significantly (p < 0.01) decreased tyrosine hydroxylase expression in the nucleus accumbens. Chronic T. laurifolia administration alone did not cause any change in the behaviours and tyrosine hydroxylase expression. Interestingly, daily administration of T. laurifolia prior to ethanol administration prevented ethanol-induced addictive behaviour and significantly (p< 0.01) increased tyrosine hydroxylase expression in the nucleus accumbens. Therefore, it can be concluded from our results that daily pre-administration of T. laurifolia can protect against ethanol-induced addiction and a decrease in dopamine synthesis in the reward system of the mesolimbic dopaminergic pathway. © 2021 Sangpayap et al.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17528
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100578817&doi=10.26538%2ftjnpr%2fv5i1.5&partnerID=40&md5=aa1820f68721aca6f0baa36fa14b55f5
ISSN: 26160684
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.