Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17438
ชื่อเรื่อง: Apoptosis Induction through MAPK Signaling Pathway in LoVo Cells by Fatty Acid Fraction from Rice Bran Oil
ผู้แต่ง: Tamvapee P.
Watanapokasin R.
วันที่เผยแพร่: 2021
บทคัดย่อ: Colorectal cancer is one of the five leading cancer incidents and mortality in Thailand and worldwide. Fatty acids (FA) are bioactive molecules which have potential as adjunctive chemotherapeutic agents. To study the effect of fatty acid fraction (FAs) extracted from organic rice bran oil on apoptosis induction and growth inhibition in human colorectal cancer cell line, LoVo cells. The results demonstrated that FAs inhibited cell viability and induced cell death via apoptosis associated with MAPKs pathway. The EC50 of FAs in LoVo was 172.80 ± 1.05 µg/ml. FAs treatment significantly increased nuclear condensation and decreased mitochondrial membrane potential. Moreover, FAs activated Bax, Caspase-9, −7 and PARP cleavage, while inhibited Bcl-2 expression. Furthermore, FAs increased p53 expression and phosphorylation of ERK and p38. FAs extracted from organic rice bran oil inhibited LoVo cell viability and induced apoptosis via MAPKs pathway. These data suggest the potential use of FAs extracted from organic rice bran oil to prevent or treat colon cancer in the future. © 2021 Taylor & Francis Group, LLC.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17438
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113729641&doi=10.1080%2f01635581.2021.1969418&partnerID=40&md5=0a685514db0012e1f69a2f5fffe95b63
ISSN: 1635581
Appears in Collections:Scopus 1983-2021

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