Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17316
ชื่อเรื่อง: Anti-inflammatory effect of probiotic Lactobacillus paracasei MSMC39-1 on alcohol-induced hepatitis in rats
ผู้แต่ง: Ladda B.
Tangteerawatana P.
Padungchaichot P.
Pradidarcheep W.
Kasorn A.
Taweechotipatr M.
วันที่เผยแพร่: 2021
บทคัดย่อ: Probiotics are good microbiota which are able to promote the health of host immunomodulation. In this study, we prepared four antigens of Lactobacillus paracasei MSMC39-1 for the detection of tumor necrosis factor-a (TNFa) secretion in hepatocellular carcinoma cell line (HepG-2). We found that viable cells and heat-killed cells of L. paracasei MSMC39-1 exhibited strong TNF-a secretion inhibitors. Viable cells of L. paracasei MSMC39-1 treatment significantly reduced serum level of aspartate aminotransferase in hepatitis rats. TNF-a secretion in liver tissues of hepatitis rats in probiotic L. paracasei MSMC39-1 treatment was significantly suppressed. Liver histopathology examination of alcohol-induced hepatitis indicated fat accumulation in the hepatocytes. Interestingly, liver damage in hepatitis rats was improved by probiotic L. paracasei MSMC39-1. In addition, L. paracasei MSMC39-1 alleviated colon inflammation in alcohol-induced hepatitis rats. Administration of L. paracasei MSMC39-1 modulated gut microbiota by increasing the number of genera Lactobacillus and Bifidobacterium in alcohol-induced hepatitis rats. We conclude that L. paracasei MSMC39-1 has potent anti-inflammatory effects on HepG-2 cell line and improves hepatitis, colon inflammation, and modulates gut microbiota. Thus L. paracasei MSMC39-1 is able to protect against alcoholic hepatitis. It can also be used as an alternative treatment in other inflammation diseases and applied in nutraceutical and dietary supplement products. © 2021. Boonyarut Ladda et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17316
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104269935&doi=10.7324%2fJAPS.2021.110407&partnerID=40&md5=67c8e0f124171f246a07fd71801297ff
ISSN: 22313354
Appears in Collections:Scopus 1983-2021

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