Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17175
ชื่อเรื่อง: The association of the APOC3 and APOA5 gene polymorphisms with dyslipidemia in Thais
ผู้แต่ง: Chuenta W.
Cheewaphan A.
Lee B.
Wannaiampikul S.
Keywords: apolipoprotein A5
apolipoprotein A6
cholesterol
high density lipoprotein cholesterol
low density lipoprotein cholesterol
triacylglycerol
unclassified drug
adult
anthropometric parameters
anthropometry
APOA5 gene
APOC3 gene
Article
blood pressure monitoring
body weight
controlled study
DNA extraction
DNA polymorphism
dyslipidemia
female
gene
gene frequency
gene linkage disequilibrium
gene sequence
genetic association
genetic polymorphism
genetic variation
genotype phenotype correlation
haplotype
Hardy Weinberg Equilibrium
human
intra-abdominal fat
major clinical study
male
middle aged
polymerase chain reaction
restriction fragment length polymorphism
single nucleotide polymorphism
spectrophotometry
Thai (people)
waist circumference
วันที่เผยแพร่: 2021
บทคัดย่อ: Background: Although the association between the apolipoprotein A5 (APOA5), and apolipoprotein C3 (APOC3) genetic variants with dyslipidemia have been extensively studied in various populations. However, the association between the apolipoprotein A5 (APOA5), and apolipoprotein C3 (APOC3) genetic variants with dyslipidemia was limited in Thai population. Objective: The present study was to examine whether APOA5 and APOC3 gene polymorphisms associated with increased risk of developing dyslipidemia in Thais. Materials and Methods: Two hundred participants were recruited in case-control studies, Four SNPs in APOC3 (rs2854116 T/C, rs2854117 C/T, rs5128 G/C) and APOA5 (rs651821 T/C) genes were genotyped by PCR-RFLP methods. Results: The results showed that polymorphism in rs651821 of APOA5 gene was significantly associated with high triglyceride levels (p=0.017). The risk of dyslipidemia increased for carrying T/C+C/C genotypes and C allele of rs651821 in APOA5 gene were 2.02 (OR: 2.02, 95% CI: 1.07 to 3.79, p=0.028) and 2.27 (OR: 2.27, 95% CI: 1.10 to 4.69, p=0.025), respectively. The haplotype analysis of variants in APOC3 (rs2854116, rs2854117, rs5128) and APOA5 (rs651821) genes, carrying with CTCC haplotype was significantly higher the risk of dyslipidemia (OR: 3.42, 95% CI: 1.23 to 9.49, p=0.019), compared with the common haplotype (TCGT). Conclusion: The risk allele (C allele) in rs651821 of APOA5 gene was associated with increasing risk of dyslipidemia by 2 times, and also haplotype carriers of APOC3 (rs2854116 (C), rs2854117 (T), rs5128 (C)) and APOA5 (rs651821 (C)) genes have higher risk of developing dyslipidemia by 3 times in Thai population. However, the association between SNPs in APOC3 gene and dyslipidemia was not observed in the present study. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17175
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116034970&doi=10.35755%2fjmedassocthai.2021.S03.00010&partnerID=40&md5=edb31a330e6f4e43d197b9d4102fdf83
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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