Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15451
ชื่อเรื่อง: Ethyl cellulose microcapsules for protecting and controlled release of folic acid
ผู้แต่ง: Prasertmanakit S.
Praphairaksit N.
Chiangthong W.
Muangsin N.
Keywords: acetone
ethyl cellulose
folic acid
liquid paraffin
methanol
solvent
sorbitan oleate
sucrose
article
concentration (parameters)
controlled release formulation
controlled study
dispersion
drug absorption
drug capsule
drug degradation
drug delivery system
drug release
drug stability
emulsion
evaporation
high performance liquid chromatography
in vitro study
microencapsulation
particle size
scanning electron microscopy
stomach juice
Capsules
Cellulose
Delayed-Action Preparations
Emulsions
Folic Acid
Hydrogen-Ion Concentration
Microscopy, Electron, Scanning
Solubility
Tablets
วันที่เผยแพร่: 2009
บทคัดย่อ: Ethyl cellulose microcapsules were developed for use as a drug-delivery device for protecting folic acid from release and degradation in the undesirable environmental conditions of the stomach, whilst allowing its release in the intestinal tract to make it available for absorption. The controlled release folic acid-loaded ethyl cellulose microcapsules were prepared by oil-in-oil emulsion solvent evaporation using a mixed solvent system, consisting of a 9:1 (v/v) ratio of acetone:methanol and light liquid paraffin as the dispersed and continuous phase. Span 80 was used as the surfactant to stabilize the emulsion. Scanning electron microscopy revealed that the microcapsules had a spherical shape. However, the particulate properties and in vitro release profile depended on the concentrations of the ethyl cellulose, Span 80 emulsifier, sucrose (pore inducer), and folic acid. The average diameter of the microcapsules increased from 300 to 448μm, whilst the folic acid release rate decreased from 52% to 40%, as the ethyl cellulose concentration was increased from 2.5% to 7.5% (w/v). Increasing the Span 80 concentration from 1% to 4% (v/v) decreased the average diameter of microcapsules from 300 to 141μm and increased the folic acid release rate from 52% to 79%. The addition of 2.5-7.5% (w/v) of sucrose improved the folic acid release from the microcapsules. The entrapment efficiency was improved from 64% to 88% when the initial folic acid concentration was increased from 1 to 3 mg/ml. © 2009 American Association of Pharmaceutical Scientists.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15451
https://www.scopus.com/inward/record.uri?eid=2-s2.0-75549084300&doi=10.1208%2fs12249-009-9305-3&partnerID=40&md5=d404a5b37926252fb7fe88a44217ff6f
ISSN: 15309932
Appears in Collections:Scopus 1983-2021

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