Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15409
ชื่อเรื่อง: Stability of barakol under hydrolytic stress conditions and its major degradation product
ผู้แต่ง: Chantong B.
Wongtongtair S.
Nusuetrong P.
Sotanaphun U.
Chaichantipyuth C.
Meksuriyen D.
Keywords: anxiolytic agent
barakol
unclassified drug
anxiolytic agent
barakol
benzopyran derivative
phenalene derivative
article
drug degradation
drug half life
drug isolation
drug oxidation
drug stability
drug structure
high performance liquid chromatography
hydrolysis
liquid chromatography
mass spectrometry
nuclear magnetic resonance
oxidative stress
pH measurement
photolysis
Senna
shelf life
temperature sensitivity
chemical structure
chemistry
pH
temperature
Fabaceae
Kobus
Senna siamea
Anti-Anxiety Agents
Benzopyrans
Drug Stability
Hydrogen-Ion Concentration
Hydrolysis
Molecular Structure
Phenalenes
Senna Plant
Temperature
วันที่เผยแพร่: 2009
บทคัดย่อ: The aim of the present study was to investigate the stability of barakol, an anxiolytic constituent extracted from leaves of Senna siamea (Lam.) Irwin & Barneby (syn. Cassia siamea Lam.), under the International Conference on Harmonisation suggested conditions using HPLC with photodiode array detection. Extensive degradation of barakol was found to occur under alkaline conditions through base-catalyzed hydrolysis. Mild degradation of barakol was observed under thermal and oxidative stress while it was stable under acidic conditions. The reaction rate constants (kobs) of barakol degradation under alkaline conditions at pHs 12 and 13 were 3.0x10-5 and 9.6x10 -3 min-1, respectively. The activation energy according to the Arrhenius plotwas calculated to be 26.9 ± 3.3 kcal/mol at pH 13 and temperatures between 12 and 51 °C. The major degradation product of barakol under both alkaline and thermal stress conditions was characterized by LC-MS and NMR as cassiachromone. © Georg Thieme Verlag KG Stuttgart.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15409
https://www.scopus.com/inward/record.uri?eid=2-s2.0-65649111135&doi=10.1055%2fs-0028-1112206&partnerID=40&md5=f31f90eb7f2de91623dbac7725bf8bde
ISSN: 320943
Appears in Collections:Scopus 1983-2021

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