Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15114
ชื่อเรื่อง: Immunohistochemical demonstration of opioids and tachykinins in human pineal gland.
ผู้แต่ง: Phansuwan-Pujito P.
Govitrapong P.
Møller M.
Keywords: opiate peptide
tachykinin
article
cadaver
human
metabolism
pathology
pineal body
Cadaver
Humans
Opioid Peptides
Pineal Gland
Tachykinins
วันที่เผยแพร่: 2005
บทคัดย่อ: The human pineal gland secretes melatonin in a circadian rhythm manner. The rhythm of melatonin synthesis is primarily controlled by the noradrenergic sympathetic system originating from the superior cervical ganglion. Several neurotransmitters/neuropeptides have been reported to influence the production of melatonin in the pineal glands of many mammalian species. Both opioid peptide, a pain suppressing peptide and substance P, a pain inducing peptide were also reported to be present in the pineal gland of several kinds of mammals. However, few studies have been demonstrated in humans. Therefore, in the present study, the immunohistochemical investigation was performed in the human pineal gland by using antisera raised against leu-enkephalin, met-enkephalin and beta-endorphin to demonstrate an opioidergic system; and antisera raised against substance P, neurokinin A, and neurokinin B to study a tachykinin system. A high amount of leu- and met-enkephalin immunoreactivities were observed in intrapineal neuronal-like cells while very few were presented in nerve fibers. This result suggests a local regulatory function or paracrine opioidergic control in human pineal. Substance P- and neurokinin A-immunoreactivities, but not neurokinin B were observed in the human pineal gland. They are located mostly in nerve fibers but a few in neuronal-like cells. The tachykininergic control of human pineal is mainly from the nerve fibers which have their perikaryal origin outside the gland. Some of the nerve fibers might originate from neurons in the brain and/or from a peripheral ganglion.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15114
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33748468806&partnerID=40&md5=11d5d0748e0676949f120fe9b8f56ce7
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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