Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15038
ชื่อเรื่อง: Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana
ผู้แต่ง: Suksamrarn S.
Komutiban O.
Ratananukul P.
Chimnoi N.
Lartpornmatulee N.
Suksamrarn A.
Keywords: 11 hydroxy 1 isomangostin
8 desoxygartanin
alpha mangostin
antineoplastic agent
demethylcalabaxanthone
gamma mangostin
garcinone b
garcinone c
garcinone d
garcinone e
gartanin
mangostanin
mangostanol
mangostenones c
mangostenones d
mangostenones e
mangostin
mangostinone
thwaitesixanthone
unclassified drug
xanthone derivative
article
breast cancer
cancer cell culture
controlled study
cytotoxicity
drug effect
drug isolation
drug structure
fruit
Garcinia mangostana
human
human cell
IC 50
lung small cell cancer
mass spectrometry
nonhuman
nuclear magnetic resonance
squamous cell carcinoma
Antineoplastic Agents, Phytogenic
Carbohydrate Conformation
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fruit
Garcinia
Humans
Magnetic Resonance Spectroscopy
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Xanthines
วันที่เผยแพร่: 2006
บทคัดย่อ: Three new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC50 values of 2.8, 3.53, and 3.72 μg/ml, respectively. Among the isolates, α-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC50 value of 0.92 μg/ml, an activity greater than that of the standard drug ellipticine (IC 50=1.46 mg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 μg/ml and 1.08 μg/ml. © 2006 Pharmaceutical Society of Japan.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15038
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645225308&doi=10.1248%2fcpb.54.301&partnerID=40&md5=1b715d7fd1657772b8ec277a8814a08d
ISSN: 92363
Appears in Collections:Scopus 1983-2021

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