Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15033
ชื่อเรื่อง: Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana
ผู้แต่ง: Suksamrarn S.
Panseeta P.
Kunchanawatta S.
Distaporn T.
Ruktasing S.
Suksamrarn A.
Keywords: 2 o 4 coumaroyl alphitolic acid
3 o (4 hydroxy 3 methoxybenzoyl)ceanothic acid (3 o vanillylceanothic acid
alphitolic acid
betulic acid
betulinaldehyde
ceanothic acid
lupeol
plant extract
triterpene derivative
unclassified drug
ziziphus cambodiana extract
zizyberanalic acid
zizyberenalic acid
antibacterial activity
antimalarial activity
article
drug isolation
drug structure
human
IC 50
jujube
minimum inhibitory concentration
Mycobacterium tuberculosis
nonhuman
Plasmodium falciparum
spectroscopy
Animals
Anti-Bacterial Agents
Antimalarials
Ceanothus
Inhibitory Concentration 50
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis
Plant Roots
Plasmodium falciparum
Triterpenes
Ziziphus
วันที่เผยแพร่: 2006
บทคัดย่อ: One new and eight known ceanothane- and lupane-type triterpenes were isolated from the root bark of Ziziphus cambodiana PIERRE (Rhamnaceae). Based on spectral analyses, the structure of the new compound was elucidated as 3-O-(4-hydroxy-3-methoxybenzoyl)ceanothic acid (3-O-vanillylceanothic acid) (1), while the known compounds were identified as lupeol (2), betulinaldehyde (3), betulinic acid (4), 2-O-E-p-coumaroyl alphitolic acid (5), alphitolic acid (6), zizyberanalic acid (7), zizyberenalic acid (8) and ceanothic acid (9). Compounds 1, 5 and 8 exhibited significant in vitro antiplasmodial activity against the parasite Plasmodium falciparum, with inhibitory concentration (IC50) values of 3.7, 0.9 and 3.0 μg/ml, respectively. Compounds 1 and 3-8 showed antimycobacterial activity against Mycobacterium tuberculosis with respective MIC values of 25, 25, 25, 12.5, 50, 50 and 100 μg/ml. © 2006 Pharmaceutical Society of Japan.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15033
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645554565&doi=10.1248%2fcpb.54.535&partnerID=40&md5=a7c291ff6ac84137bd0f0759fe9df414
ISSN: 92363
Appears in Collections:Scopus 1983-2021

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