Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14971
ชื่อเรื่อง: Cytokine production in NK and NKT cells from Mycobacterium tuberculosis infected patients
ผู้แต่ง: Kulpraneet M.
Sukwit S.
Sumransurp K.
Chuenchitra T.
Santiwatanakul S.
Srisurapanon S.
วันที่เผยแพร่: 2007
บทคัดย่อ: Tuberculosis, a major health problem in developing countries, has re-emerged in recent years in many countries. While it is accepted that various lymphocyte subsets are Important responses to mycobacterial infection, the roles of NK and NKT cells in producing cytokines are still unclear. Thus we have evaluated, in Mycobacterium tuberculosis infection, the frequency of cytokine producing cells by flow cytometry. Of 30 individuals examined, 17 had clinical evidence of pulmonary tuberculosis while the rest showed no evidence of infection. Patients had a significantly higher number of IFN-γ and IL-4-producing T cells compared to control subjects, but the ratio of IFN-γ to IL-4-producing T cells was similar in both groups. There were no differences between cytokine profiles of NK cells in patients and control subjects. A significant increase in the number of NKT cells was observed in patients. A striking finding was the higher frequency of IL-4-producing NKT cells compared to IFN-γ-producing cells. Moreover, individual NKT cell produced both IFN-γ and IL-4. The preferential type of Th1 or Th2 cells is due to mycobacterial strain, type of antigen presenting cells and stage of disease, all of which can lead to different patterns of cytokine production by variety of lymphocyte subsets.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14971
https://www.scopus.com/inward/record.uri?eid=2-s2.0-34249699152&partnerID=40&md5=58806e9e060876c849aabb36b818f309
ISSN: 1251562
Appears in Collections:Scopus 1983-2021

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