Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14956
ชื่อเรื่อง: Antibacterial Pterocarpans from Erythrina subumbrans
ผู้แต่ง: Rukachaisirikul T.
Innok P.
Aroonrerk N.
Boonamnuaylap W.
Limrangsun S.
Boonyon C.
Woonjina U.
Suksamrarn A.
Keywords: 5 hydroxysophoranone
erybraedin a
erycristagallin
erystagallin a
erysubin f
erythrabissin 1
erythrabyssin ii
flavanone derivative
glabrol
isoflavone
oxacillin
phaseolin
pterocarpan derivative
unclassified drug
vancomycin
antibacterial activity
article
drug isolation
drug structure
Erythrina
Erythrina subumbrans
methicillin resistant Staphylococcus aureus
minimum inhibitory concentration
nonhuman
plant stem
Staphylococcus
Streptococcus
Anti-Bacterial Agents
Drug Resistance, Bacterial
Erythrina
Flavones
Isoflavones
Microbial Sensitivity Tests
Molecular Structure
Pterocarpans
Staphylococcus
Erythrina (angiosperm)
Erythrina subumbrans
Fabaceae
methicillin resistant Staphylococcus aureus
Staphylococcus
Streptococcus
วันที่เผยแพร่: 2007
บทคัดย่อ: Seven pterocarpans, erybraedin B (1), erybraedin A (2), phaseollin (3), erythrabyssin II (4), erystagallin A (5), erythrabissin-1 (6) and erycristagallin (7), two flavanones, 5-hydroxysophoranone (8) and glabrol (9), and one isoflavone, erysubin F (10), were isolated from the stems of Erythrina subumbrans (Leguminosae). Their structures were identified by means of spectroscopy. This is the first report of the isolation of the non-alkaloidal compounds from Erythrina subumbrans and the observed dehydration of 6a-hydroxypterocarpans 5 and 6 in CDCl3 to the corresponding pterocarpenes 11 and 12, respectively. Compounds 8 and 9 were isolated for the first time from the genus Erythrina. Compounds 2 and 4 exhibited the highest degree of activity against Streptococcus strains with an MIC range of 0.78-1.56 μg/ml, whereas compound 7 exhibited the highest degree of activity against Staphylococcus strains, including drug-resistant strains (MRSA and VRSA), with an MIC range of 0.39-1.56 μg/ml. Interestingly, compounds 2, 4, 5 and 7 were more active against several strains of Streptococcus and Staphylococcus than the standard antibiotics vancomycin and oxacillin. Compound 7 showed the highest level of activity against all VRSA strains tested, with an MIC range of 0.39-1.56 μg/ml, which were resistant to both antibiotics. These compounds may prove to be potent phytochemical agents for antibacterial activity, especially against the MRSA and VRSA strains. © 2006 Elsevier Ireland Ltd. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14956
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846787105&doi=10.1016%2fj.jep.2006.09.022&partnerID=40&md5=021ca5fa4437837ea4aa203f0d0afc20
ISSN: 3788741
Appears in Collections:Scopus 1983-2021

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