Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14871
ชื่อเรื่อง: The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves
ผู้แต่ง: Chumark P.
Khunawat P.
Sanvarinda Y.
Phornchirasilp S.
Morales N.P.
Phivthong-ngam L.
Ratanachamnong P.
Srisawat S.
Pongrapeeporn K.-u.S.
Keywords: 1,1 diphenyl 2 picrylhydrazyl
alkadiene
cholesterol
copper
low density lipoprotein
Moringa oleifera extract
simvastatin
thiobarbituric acid reactive substance
trolox C
analytic method
animal experiment
animal model
animal tissue
anticoagulation
antioxidant activity
article
atherosclerotic plaque
cholesterol blood level
cholesterol diet
comparative study
controlled study
dose response
hypolipemia
male
Moringa oleifera
nonhuman
oxidation
rabbit
Animals
Antilipemic Agents
Antioxidants
Atherosclerosis
Body Weight
Cholesterol
Cholesterol, Dietary
Humans
Lipids
Lipoproteins, LDL
Male
Moringa oleifera
Picrates
Plant Extracts
Plant Leaves
Rabbits
Simvastatin
Thiobarbituric Acid Reactive Substances
Vitamin E
Water
Moringa oleifera
Moringaceae
Oryctolagus cuniculus
วันที่เผยแพร่: 2008
บทคัดย่อ: Moringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed. Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of Moringa oleifera leaf extract. Materials and Methods: Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu2+-induced low-density lipoprotein (LDL) oxidation were determined in in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated. Results: We found that in scavenging DPPH radicals the extract and Trolox® had IC50 of 78.15 ± 0.92 and 2.14 ± 0.12 μg/ml, respectively. The extract significantly (P < 0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both in vitro and ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (P < 0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin. Conclusions: The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases. © 2007 Elsevier Ireland Ltd. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14871
https://www.scopus.com/inward/record.uri?eid=2-s2.0-40249085612&doi=10.1016%2fj.jep.2007.12.010&partnerID=40&md5=039d1934cdffc43c082246ec5f7597f0
ISSN: 3788741
Appears in Collections:Scopus 1983-2021

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