Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14855
ชื่อเรื่อง: Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens
ผู้แต่ง: Spinler J.K.
Taweechotipatr M.
Rognerud C.L.
Ou C.N.
Tumwasorn S.
Versalovic J.
Keywords: 3 hydroxypropionaldehyde
antiinfective agent
glycerol
glycerol derivative
probiotic agent
reuterin
absorption spectrophotometry
article
bacterial growth
bacterium culture
enterohemorrhagic Escherichia coli
enterotoxigenic Escherichia coli
gastroenteritis
Gram negative bacterium
Gram positive bacterium
growth inhibition
high performance liquid chromatography
intestine flora
lactic acid bacterium
Lactobacillus
Lactobacillus reuteri
minimum inhibitory concentration
nonhuman
priority journal
Salmonella enterica
Shigella sonnei
strain difference
Vibrio cholerae
Antibiosis
Enterohemorrhagic Escherichia coli
Enterotoxigenic Escherichia coli
Female
Gastroenteritis
Glyceraldehyde
Gram-Negative Bacteria
Humans
Intestines
Lactobacillus reuteri
Microbial Sensitivity Tests
Probiotics
Propane
Salmonella enterica
Shigella sonnei
Vibrio cholerae
Bacteria (microorganisms)
Escherichia coli
Lactobacillus reuteri
Negibacteria
Posibacteria
Salmonella enterica
Shigella sonnei
Vibrio cholerae
วันที่เผยแพร่: 2008
บทคัดย่อ: Lactobacillus reuteri is a commensal-derived anaerobic probiotic that resides in the human gastrointestinal tract. L. reuteri converts glycerol into a potent broad-spectrum antimicrobial compound, reuterin, which inhibits the growth of gram-positive and gram-negative bacteria. In this study, we compared four human-derived L. reuteri isolates (ATCC 55730, ATCC PTA 6475, ATCC PTA 4659 and ATCC PTA 5289) in their ability to produce reuterin and to inhibit the growth of different enteric pathogens in vitro. Reuterin was produced by each of the four L. reuteri strains and assessed for biological activity. The minimum inhibitory concentration (MIC) of reuterin derived from each strain was determined for the following enteric pathogens: enterohemorrhagic Escherichia coli, enterotoxigenic E. coli, Salmonella enterica, Shigella sonnei and Vibrio cholerae. We also analyzed the relative abilities of L. reuteri to inhibit enteric pathogens in a pathogen overlay assay. The magnitude of reuterin production did not directly correlate with the relative ability of L. reuteri to suppress the proliferation of enteric pathogens. Additional antimicrobial factors may be produced by L. reuteri, and multiple factors may act synergistically with reuterin to inhibit enteric pathogens. © 2008 Elsevier Ltd. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14855
https://www.scopus.com/inward/record.uri?eid=2-s2.0-44649149490&doi=10.1016%2fj.anaerobe.2008.02.001&partnerID=40&md5=6d0b5a62dab6b0e9703af3289265dd37
ISSN: 10759964
Appears in Collections:Scopus 1983-2021

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