Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14834
ชื่อเรื่อง: The Thai anesthesia incident monitoring study of perioperative allergic reactions: An analysis of 1996 incidents reports
ผู้แต่ง: Lapisatepun W.
Charuluxananan S.
Kusumaphanyo C.
Ittichaikulthol W.
Suksompong S.
Ratanachai P.
Keywords: antibiotic agent
antihistaminic agent
atracurium
bronchodilating agent
cephalosporin
cloxacillin
corticosteroid
fentanyl
fresh frozen plasma
gelatin
hypertensive agent
metronidazole
morphine
neuromuscular blocking agent
opiate
pethidine
plasma substitute
propofol
rocuronium
suxamethonium
thiopental
vecuronium
adult
article
bronchospasm
clinical article
clinical trial
disease severity
drug hypersensitivity
drug surveillance program
erythrocyte concentrate
female
human
hypotension
male
multicenter study
perioperative complication
sex difference
skin manifestation
Thailand
Adolescent
Adult
Adverse Drug Reaction Reporting Systems
Aged
Aged, 80 and over
Analgesics, Opioid
Anesthesia
Anti-Bacterial Agents
Child
Child, Preschool
Drug Hypersensitivity
Drug Monitoring
Female
Health Status Indicators
Humans
Hypersensitivity
Incidence
Male
Middle Aged
Neuromuscular Agents
Perioperative Care
Prospective Studies
Risk Factors
Succinylcholine
Thailand
Young Adult
วันที่เผยแพร่: 2008
บทคัดย่อ: Objectives: Analyze the clinical course, management, outcome, and contributing factors of perioperative allergic reactions in the Thai Anesthesia Incident Monitoring Study (Thai AIMS). Material and Method: A prospective descriptive multicenter study was conducted in 51 hospitals across Thailand. Voluntary, anonymous reports of any adverse or undesirable events during the first 24 hours of anesthesia were sent to the Thai AIMS data management unit. Possible perioperative allergic reactions were extracted and examined independently by three peer reviewers. Results: Forty-three reports of possible perioperative allergic reactions from the 2,537 incidents reported to the Thai AIMS (1.6%) were reviewed. There was a female predominance (1.9:1). The most common features were cutaneous manifestations (93%), arterial hypotension (20.1%), and bronchospasm (11.6%) respectively. The severity grades were 69.8% in grade I, 4.7% in grade II, and 25.6% in grade III. The three most suspected causative agents were neuromuscular blocking agents (39.5%, 30.2%- succinylcholine), antibiotics (27.9%), and opioids (18.6%) respectively. All but one responded well to treatment with complete recovery. One patient suffered acute myocardial infarction and had to stay at the hospital for longer than one week. None had further allergic reaction. Conclusion: Perioperative allergic reactions accounted for 1.6% of anesthetic adverse events. The most common features were cutaneous manifestations. A quarter of these were life-threatening but responded well to treatment. The most common suspected causative agent was succinylcholine.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14834
https://www.scopus.com/inward/record.uri?eid=2-s2.0-55249120206&partnerID=40&md5=996164a9fa66b3ba94a7cab3889d1d28
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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