Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14781
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dc.contributor.authorNittayananta W.
dc.contributor.authorTalungchit S.
dc.contributor.authorJaruratanasirikul S.
dc.contributor.authorSilpapojakul K.
dc.contributor.authorChayakul P.
dc.contributor.authorNilmanat A.
dc.contributor.authorPruphetkaew N.
dc.date.accessioned2021-04-05T03:37:13Z-
dc.date.available2021-04-05T03:37:13Z-
dc.date.issued2010
dc.identifier.issn9042512
dc.identifier.other2-s2.0-77951284331
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77951284331&doi=10.1111%2fj.1600-0714.2009.00875.x&partnerID=40&md5=2750d63e3a2aa6464b3007e4fc9c7d59
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/14781-
dc.description.abstractJ Oral Pathol Med (2010) 39: 397-406 Background: The aim of this study was to determine the effects of long-term use of highly active antiretroviral therapy (HAART) on oral health status of HIV-infected subjects. Methods: Oral examination and measurement of saliva flow rate of both unstimulated and wax-stimulated whole saliva were performed in HIV-infected subjects with and without HAART, and in non-HIV individuals. The following data were recorded; duration and risk of HIV infection, type and duration of HAART, CD4 cell count, viral load, presence of orofacial pain, oral dryness, oral burning sensation, oral lesions, cervical caries, and periodontal pocket. Multiple logistic regression analysis was performed to determine the effects of long-term use of HAART on oral health status of HIV-infected subjects. Results: One hundred and fifty-seven HIV-infected subjects - 99 on HAART (age range 23-57 years, mean 39 years) and 58 not on HAART (age range 20-59 years, mean 34 years) - and 50 non-HIV controls (age range 19-59 years, mean 36 years) were enrolled. The most common HAART regimen was 2 NRTI + 2 NNRTI. HIV-infected subjects without HAART showed greater risks of having orofacial pain, oral dryness, oral lesions, and periodontal pockets than those with short-term HAART (P < 0.01). The subjects with long-term HAART were found to have a greater risk of having oral lesions than those with short-term HAART (P < 0.05). The unstimulated and stimulated salivary flow rates of the subjects with HAART were significantly lower than in those without HAART (P < 0.05). Conclusion: We conclude that long-term HAART has adverse effects on oral health status of HIV-infected subjects. © 2010 John Wiley & Sons A/S.
dc.subjectantiretrovirus agent
dc.subjectadult
dc.subjectage distribution
dc.subjectagglutination test
dc.subjectarticle
dc.subjectburning sensation
dc.subjectCD4 lymphocyte count
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdosage schedule comparison
dc.subjectdrug exposure
dc.subjectfemale
dc.subjectflow rate
dc.subjectgingiva bleeding
dc.subjecthairy leukoplakia
dc.subjecthealth status
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjectlong term care
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmouth
dc.subjectmouth examination
dc.subjectmouth lesion
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectrisk assessment
dc.subjectsalivation
dc.subjectshort course therapy
dc.subjectthrush
dc.subjecttreatment duration
dc.subjectvirus load
dc.subjectxerostomia
dc.subjectcase control study
dc.subjectcomplication
dc.subjectdental caries
dc.subjectdrug effects
dc.subjecthealth
dc.subjecthealth status
dc.subjecthighly active antiretroviral therapy
dc.subjectHIV Infections
dc.subjectmiddle aged
dc.subjectmouth disease
dc.subjectperiodontics
dc.subjectPigmentation Disorders
dc.subjectsecretion rate
dc.subjectstatistical model
dc.subjectThailand
dc.subjecttime
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAntiretroviral Therapy, Highly Active
dc.subjectCase-Control Studies
dc.subjectCross-Sectional Studies
dc.subjectDental Caries
dc.subjectFemale
dc.subjectHealth Status
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectLinear Models
dc.subjectLogistic Models
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Diseases
dc.subjectOral Health
dc.subjectPeriodontal Index
dc.subjectPigmentation Disorders
dc.subjectSalivation
dc.subjectSecretory Rate
dc.subjectThailand
dc.subjectTime Factors
dc.subjectYoung Adult
dc.titleEffects of long-term use of HAART on oral health status of HIV-infected subjects
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Oral Pathology and Medicine. Vol 39, No.5 (2010), p.397-406
dc.identifier.doi10.1111/j.1600-0714.2009.00875.x
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