Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14674
ชื่อเรื่อง: Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone
ผู้แต่ง: Sotthibundhu A.
Phansuwan-Pujito P.
Govitrapong P.
Keywords: adenylate cyclase
luzindole
melatonin
melatonin receptor
pertussis toxin
animal cell
article
cell culture
cell differentiation
cell proliferation
concentration response
controlled study
glia cell
mouse
nerve degeneration
nervous system development
neural stem cell
nonhuman
stem cell transplantation
subventricular zone
upregulation
Analysis of Variance
Animals
Antioxidants
Blotting, Western
Cell Proliferation
Cells, Cultured
Immunohistochemistry
Lateral Ventricles
Melatonin
Mice
Neural Stem Cells
Receptors, Melatonin
Tryptamines
วันที่เผยแพร่: 2010
บทคัดย่อ: Melatonin, a circadian rhythm-promoting molecule secreted mainly by the pineal gland, has a variety of biological functions and neuroprotective effects including control of sleep-wake cycle, seasonal reproduction, and body temperature as well as preventing neuronal cell death induced by neurotoxic substances. Melatonin also modulates neural stem cell (NSC) function including proliferation and differentiation in embryonic brain tissue. However, the involvement of melatonin in adult neurogenesis is still not clear. Here, we report that precursor cells from adult mouse subventricular zone (SVZ) of the lateral ventricle, the main neurogenic area of the adult brain, express melatonin receptors. In addition, precursor cells derived from this area treated with melatonin exhibited increased proliferative activity. However, when cells were treated with luzindole, a competitive inhibitor of melatonin receptors, or pertussis toxin, an uncoupler of Gi from adenylate cyclase, melatonin-induced proliferation was reduced. Under these conditions, melatonin induced the differentiation of precursor cells to neuronal cells without an upregulation of the number of glia cells. Because stem cell replacement is thought to play an important therapeutic role in neurodegenerative diseases, melatonin might be beneficial for stimulating endogenous neural stem cells. © 2010 John Wiley & Sons A/S.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14674
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956299657&doi=10.1111%2fj.1600-079X.2010.00794.x&partnerID=40&md5=f10e445ea127f7bae100b627e5033323
ISSN: 7423098
Appears in Collections:Scopus 1983-2021

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