Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14629
ชื่อเรื่อง: Clinical features, management and outcomes of high-grade glioma patients in Ramathibodi Hospital
ผู้แต่ง: Chansriwong P.
Sirisinha T.
Keywords: alkylating agent
carmustine
dacarbazine
drug derivative
temozolomide
adolescent
adult
aged
article
brain tumor
disease free survival
evaluation
female
follow up
glioma
hospital
human
incidence
male
middle aged
multimodality cancer therapy
pathology
prognosis
proportional hazards model
retrospective study
survival
treatment outcome
Adolescent
Adult
Aged
Antineoplastic Agents, Alkylating
Brain Neoplasms
Carmustine
Combined Modality Therapy
Dacarbazine
Disease-Free Survival
Female
Follow-Up Studies
Glioma
Hospitals
Humans
Incidence
Male
Middle Aged
Prognosis
Proportional Hazards Models
Retrospective Studies
Survival Analysis
Treatment Outcome
Young Adult
วันที่เผยแพร่: 2010
บทคัดย่อ: Objective: To identify prognostic factors for survival and evaluate the effect of treatment on survival of patients with high-grade glioma treated at Ramathibodi Hospital. Material and Method: Medical records of patients with diagnosis of high-grade glioma registered in Ramathibodi cancer registry were reviewed. A total of 36 patients were reviewed, only 27 patients were included on survival analysis. Results: Of the 36 patients, the male: female ratio was 1:1. Mean age of diagnosis was 41.86 years (range 18- 71 years). Histological findings were anaplastic glioma (22.20%), glioblastoma multiforme (63.90%) and mixed glioma (13.90%). Of fifteen patients underwent total tumor removal, 17 patients had partial resection and in 4 cases biopsy alone was done. Two third of the patients had received radiotherapy with mean total dose 5,372 cGy. Nine patients also received chemotherapy (6 temozolomide and 3 BCNU). Median follow-up time was 413.2 days. An overall survival time was 604.04 days and median disease free survival time was 402.45 days. In univariated analysis, the following favorable prognostic factors were identified: histological findings of glioblastoma multiforme (GBM) and mixed glioma, received radiotherapy. In multivariate analysis, radiotherapy improves overall survival significantly. Re-resection at recurrence did not appear to improve overall survival. Conclusion: Adult high-grade glioma had poor prognosis despite aggressive treatment. Radiotherapy significantly improved survival while surgical tumor removal and chemotherapy did not. However due to the small number of patients the further studies should be performed.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14629
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952270315&partnerID=40&md5=7d900215a6e730a89c7910701da9cb4f
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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