Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14603
ชื่อเรื่อง: Transspecies dimorphic allelic lineages of the proteasome subunit β-type 8 gene (PSMB8) in the teleost genus Oryzias
ผู้แต่ง: Miura F.
Tsukamoto K.
Mehta R.B.
Naruse K.
Magtoon W.
Nonaka M.
Keywords: major histocompatibility antigen class 1
proteasome subunit beta type 8
protein
unclassified drug
allele
amino acid analysis
amino acid sequence
amino acid substitution
article
evolution
exon
gene sequence
intron
nonhuman
nucleotide sequence
Oryzias
priority journal
species differentiation
teleost
vertebrate
Alleles
Amino Acid Sequence
Animals
Base Sequence
Evolution, Molecular
Histocompatibility Antigens Class I
Major Histocompatibility Complex
Molecular Sequence Data
Oryzias
Phylogeny
Polymorphism, Genetic
Proteasome Endopeptidase Complex
Protein Subunits
Gnathostomata (vertebrate)
Oryzias
Oryzias latipes
Oryziinae
Teleostei
วันที่เผยแพร่: 2010
บทคัดย่อ: The proteasome subunit β-type 8 (PSMB8) gene in the jawed vertebrate MHC genomic region encodes a catalytic subunit of the immunoproteasome involved in the generation of peptides to be presented by the MHC class I molecules. A teleost, the medaka (Oryzias latipes), has highly diverged dimorphic allelic lineages of the PSMB8 gene with only about 80% amino acid identity, termed "PSMB8d" and "PSMB8N," which have been retained by most wild populations analyzed. To elucidate the evolutionary origin of these two allelic lineages, seven species of the genus Oryzias were analyzed for their PSMB8 allelic sequences using a large number of individuals from wild populations. All the PSMB8 alleles of these species were classified into one of these two allelic lineages based on their nucleotide sequences of exons and introns, indicating that the Oryzias PSMB8 gene has a truly dichotomous allelic lineage. Retention of both allelic lineages was confirmed except for one species. The PSMB8d lineage showed a higher frequency than the PSMB8N lineage in all seven species. The two allelic lineages showed curious substitutions at the 31st and 53rd residues of the mature peptide, probably involved in formation of the S1 pocket, suggesting that these allelic lineages show a functional difference in cleavage specificity. These results indicate that the PSMB8 dimorphism was established before speciation within the genus Oryzias and has been maintained for more than 30-60 million years under a strict and asymmetric balancing selection through several speciation events.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14603
https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650733024&doi=10.1073%2fpnas.1012881107&partnerID=40&md5=cd73043493ec4812d00bf4a80c1cbff4
ISSN: 278424
Appears in Collections:Scopus 1983-2021

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