Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14520
ชื่อเรื่อง: Acute effects of bergamot oil on anxiety-related behaviour and corticosterone level in rats
ผู้แต่ง: Saiyudthong S.
Marsden C.A.
Keywords: 4 aminobutyric acid
4 aminobutyric acid A receptor
bergamot oil
corticosterone
diazepam
acute stress
animal experiment
animal model
anxiety
anxiety disorder
aromatherapy
article
controlled study
corticosterone blood level
emotion
GABAergic system
hypothalamic paraventricular nucleus
locomotion
male
maze test
neurotransmission
nonhuman
rat
task performance
tranquilizing activity
Administration, Inhalation
Animals
Anti-Anxiety Agents
Anxiety Disorders
Corticosterone
Diazepam
Male
Maze Learning
Oils, Volatile
Plant Extracts
Plant Oils
Rats
Rats, Wistar
Citrus aurantium
Rattus
Rutaceae
วันที่เผยแพร่: 2011
บทคัดย่อ: Bergamot essential oil (BEO), Citrus aurantium subsp. bergamia (Risso) Wright & Arn. (Rutaceae), is used widely in aromatherapy to reduce stress and anxiety despite limited scientific evidence. A previous study showed that BEO significantly increased gamma-aminobutyric acid levels in rat hippocampus, suggesting potential anxiolytic properties. The aim of this study was to investigate the effect of BEO (1.0%, 2.5% and 5.0% w/w) administered to rats on both anxiety-related behaviours (the elevated plus-maze (EPM) and hole-board tests) and stress-induced levels of plasma corticosterone in comparison with the effects of diazepam. Inhalation of BEO (1% and 2.5%) and injection of diazepam (1 mg/kg, i.p.) significantly increased the percentage of open arm entries on the EPM. The percentage time spent in the open arms was also significantly enhanced following administration of either BEO (2.5% and 5%) or diazepam. Total arm entries were significantly increased with the highest dose (5%), suggesting an increase in locomotor activity. In the hole-board test, 2.5% BEO and diazepam significantly increased the number of head dips. 2.5% BEO and diazepam attenuated the corticosterone response to acute stress caused by exposure to the EPM. In conclusion, both BEO and diazepam exhibited anxiolytic-like behaviours and attenuated HPA axis activity by reducing the corticosterone response to stress. Copyright © 2010 John Wiley & Sons, Ltd.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14520
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79957809174&doi=10.1002%2fptr.3325&partnerID=40&md5=4ca76b2ebc4fee092817500cb7eb7290
ISSN: 0951418X
Appears in Collections:Scopus 1983-2021

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