Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14402
ชื่อเรื่อง: Sox9 is upstream of microRNA-140 in cartilage
ผู้แต่ง: Nakamura Y.
He X.
Kato H.
Wakitani S.
Kobayashi T.
Watanabe S.
Iida A.
Tahara H.
Warman M.L.
Watanapokasin R.
Postlethwait J.H.
Keywords: In situ hybridization
MicroRNA-140 (miR-140)
RT-PCR
siRNA
Sox9
T/C-28
Zebrafish
Mammals
Polymerase chain reaction
RNA
Tissue
Cartilage
microRNA
microRNA 140
mutant protein
platelet derived growth factor alpha receptor
small interfering RNA
transcription factor Sox9
unclassified drug
animal experiment
article
cartilage
cartilage cell
controlled study
human
human cell
in situ hybridization
nonhuman
protein expression
reverse transcription polymerase chain reaction
transcription regulation
zebra fish
Animals
Binding Sites
Cartilage
Chondrocytes
Chondrogenesis
Embryonic Development
Gene Expression Regulation, Developmental
Humans
In Situ Hybridization
MicroRNAs
Phylogeny
Protein Binding
RNA, Small Interfering
SOX9 Transcription Factor
Ubiquitin-Protein Ligases
Zebrafish
Danio rerio
Mammalia
วันที่เผยแพร่: 2012
บทคัดย่อ: MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet-derived growth factor receptor alpha (pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a-/-) and sox9b mutant (sox9b-/-) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells. © 2011 Springer Science+Business Media, LLC.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14402
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856260583&doi=10.1007%2fs12010-011-9404-y&partnerID=40&md5=b7c62c3c83efc0cb97c7912a0ba81b75
ISSN: 2732289
Appears in Collections:Scopus 1983-2021

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