Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14401
ชื่อเรื่อง: Treatment of laryngopharyngeal reflux: A comparison between domperidone plus omeprazole and omeprazole alone
ผู้แต่ง: Hunchaisri N.
Keywords: domperidone
omeprazole
adult
aged
article
clinical article
combination chemotherapy
comparative study
controlled study
drug efficacy
drug response
female
human
laryngopharyngeal reflux
male
monotherapy
outcome assessment
prospective study
randomized controlled trial
reflux symptom index
scoring system
sex difference
Anti-Ulcer Agents
Chi-Square Distribution
Domperidone
Dopamine Antagonists
Drug Therapy, Combination
Female
Humans
Laryngopharyngeal Reflux
Male
Middle Aged
Omeprazole
Prospective Studies
Treatment Outcome
วันที่เผยแพร่: 2012
บทคัดย่อ: Objective: To evaluate the efficacy of domperidone in combination with omeprazole in the treatment of laryngopharyngeal reflux (LPR) compare to omeprazole alone. Material and Method: A prospective and randomized study included seventy patients with a reflux symptom index (RSI) 13 or more. They received either domperidone 10 mg thrice daily plus omeprazole 20 mg twice daily or omeprazole alone for three months. RSI was assessed at baseline and after three months of treatment. Results: Total RSI as well as several subscores were comparable between groups before the treatment. After three months of the treatment, moderate improvement of total RSI was shown in both groups (72.7%, 67.5%). The reduction of total RSI and individual subscores were statistically significant within each group (p < 0.001 each). Comparing between each treatment group, the mean difference of total RSI and individual subscores did not shown any statistically differences (p > 0.05 each) at the end of the study period. Conclusion: Domperidone in combination with omeprazole is not superior to omeprazole alone in the treatment of LPR.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14401
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856940056&partnerID=40&md5=e2a5ebd22003151b2097d04aa4e7a0f0
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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