Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14362
ชื่อเรื่อง: Population pharmacokinetics of mycophenolate mofetil in Thai lupus nephritis patients
ผู้แต่ง: Punyawudho B.
Lertdumrongluk P.
Somparn P.
Kittanamongkolchai W.
Traitanon O.
Avihingsanon Y.
Vadcharavivad S.
Keywords: mycophenolic acid 2 morpholinoethyl ester
prednisolone
drug derivative
immunosuppressive agent
mycophenolic acid
mycophenolic acid 2 morpholinoethyl ester
adult
article
clinical article
controlled study
disease classification
drug absorption
drug blood level
drug clearance
drug distribution
drug dose titration
female
human
lupus erythematosus nephritis
male
population research
Thailand
Asian
biological model
blood
ethnology
lupus erythematosus nephritis
Thailand
treatment outcome
Adult
Asian Continental Ancestry Group
Female
Humans
Immunosuppressive Agents
Lupus Nephritis
Male
Models, Biological
Mycophenolic Acid
Thailand
Treatment Outcome
วันที่เผยแพร่: 2012
บทคัดย่อ: Objective: Mycophenolic acid (MPA) has become the first-line drug therapy for proliferative lupus nephritis, a common and serious complication of systemic lupus erythematosus. Although a sufficient MPA exposure is required, a high interindividual variability in the pharmacokinetics of MPA has been observed. The knowledge of MPA pharmacokinetics in lupus nephritis patients is limited, especially in Asian patients. This study aimed to develop a population pharmacokinetic model for MPA and determine the population pharmacokinetic parameters and their interindividual variability in Thai patients with lupus nephritis. Methods: A total of 112 MPA plasma concentrations from 14 adult lupus nephritis patients (International Society of Nephrology/Renal Pathology Society Class III/IV) receiving mycophenolate mofetil were included in this study. The data was analyzed using NONMEM. The model evaluation was performed by the bootstrap approach and visual predictive check. Results: A two-compartment model with a lag time best described the data. The estimated mean apparent clearance (CL/F) was 14.5 l/h with an interindividual variability of 45.2%. The estimated mean CL/F was found to be lower than the values previously reported. The estimated mean apparent volume of the central compartment was 12.2 l with an interindividual variability of 166%. None of the covariates were found to significantly influence MPA pharmacokinetics. Conclusion: In this study, a population pharmacokinetic model of MPA in severe lupus nephritis patients was successfully developed. The mean pharmacokinetic parameters were estimated and a high interindividual variability of MPA in this population was observed. This provides evidence to show that individualizing dosage regimens in this population is crucial. The model developed in this study could be used to obtain initial information for MPA dose adjustments in Thai and Asian patients with lupus nephritis. Further studies are required to validate the results and clarify the influence of covariates on MMF pharmacokinetics. ©2012 Dustri-Verlag Dr. K. Feistle.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14362
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861446507&doi=10.5414%2fCP201605&partnerID=40&md5=3c396148466374eee738ce87187f1d67
ISSN: 9461965
Appears in Collections:Scopus 1983-2021

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