Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/14329
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dc.contributor.authorWitoonsaridsilp W.
dc.contributor.authorPaeratakul O.
dc.contributor.authorPanyarachun B.
dc.contributor.authorSarisuta N.
dc.date.accessioned2021-04-05T03:34:12Z-
dc.date.available2021-04-05T03:34:12Z-
dc.date.issued2012
dc.identifier.issn15309932
dc.identifier.other2-s2.0-84862904378
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84862904378&doi=10.1208%2fs12249-012-9788-1&partnerID=40&md5=874ac5247e15378814d0b1fdb0289395
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/14329-
dc.description.abstractThe lysozyme (LZ)-entrapped mannosylated liposomes were prepared in this study by the use of N-octadecyl-d-mannopyranosylamine (SAMAN), which had been synthesized in-house and confirmed by characterization with FTIR and NMR. The reactant residues of synthesized SAMAN were found to be less than 1%. The mean sizes, zeta potentials, drug entrapment efficiencies, and loading capacities of all liposomal formulations were in the ranges of 234.7 to 431.0 nm, -10.97 to -25.80 mV, 7.52 to 14.10%, and 1.44 to 2.77%, respectively. The permeability of mannosylated LZ liposomes across Caco-2 cell monolayers was significantly enhanced to about 2.5- and 7-folds over those of conventional liposomes and solution, respectively, which might be due to the role of mannose receptor or mannose-binding protein on the intestinal enterocytes. © 2012 American Association of Pharmaceutical Scientists.
dc.subjectligand
dc.subjectliposome
dc.subjectmannose
dc.subjectmannose binding protein
dc.subjectmannose receptor
dc.subjectmannosylated liposome
dc.subjectn octadecyl d mannopyranosylamine
dc.subjectunclassified drug
dc.subjectarticle
dc.subjectcell strain CACO 2
dc.subjectcell surface
dc.subjectcrystal structure
dc.subjectdrug adsorption
dc.subjectdrug formulation
dc.subjectdrug penetration
dc.subjecthuman
dc.subjecthuman cell
dc.subjectinfrared spectroscopy
dc.subjectintestine cell
dc.subjectintestine mucosa permeability
dc.subjectnuclear magnetic resonance
dc.subjectparticle size
dc.subjectphysical chemistry
dc.subjectpriority journal
dc.subjectprotein transport
dc.subjectsynthesis
dc.subjectzeta potential
dc.subjectAmino Sugars
dc.subjectBiological Transport
dc.subjectCaco-2 Cells
dc.subjectChemistry, Pharmaceutical
dc.subjectHumans
dc.subjectIntestinal Absorption
dc.subjectIntestinal Mucosa
dc.subjectKinetics
dc.subjectLectins, C-Type
dc.subjectLipids
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMannose-Binding Lectin
dc.subjectMannose-Binding Lectins
dc.subjectMuramidase
dc.subjectNanoparticles
dc.subjectParticle Size
dc.subjectPermeability
dc.subjectReceptors, Cell Surface
dc.subjectSpectroscopy, Fourier Transform Infrared
dc.subjectTechnology, Pharmaceutical
dc.titleDevelopment of mannosylated liposomes using synthesized N-octadecyl-D-mannopyranosylamine to enhance gastrointestinal permeability for protein delivery
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationAAPS PharmSciTech. Vol 13, No.2 (2012), p.699-706
dc.identifier.doi10.1208/s12249-012-9788-1
Appears in Collections:Scopus 1983-2021

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