Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14263
ชื่อเรื่อง: Astraodoric acids A-D: New lanostane triterpenes from edible mushroom astraeus odoratus and their anti-mycobacterium tuberculosis H37Ra and cytotoxic activity
ผู้แต่ง: Arpha K.
Phosri C.
Suwannasai N.
Mongkolthanaruk W.
Sodngam S.
Keywords: antituberculosis
Astraeus odoratus
astraodoric acids A-D
Cytotoxic activities
hypaphorine
Triterpenes
Cell culture
Cytotoxicity
Fungi
Spectroscopic analysis
X ray crystallography
Tubes (components)
triterpene
tuberculostatic agent
Agaricales
article
cell survival
chemistry
drug effect
human
isolation and purification
microbial sensitivity test
microbiology
Mycobacterium tuberculosis
tuberculosis
tumor cell line
Agaricales
Antitubercular Agents
Cell Line, Tumor
Cell Survival
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Triterpenes
Tuberculosis
Astraeus odoratus
Basidiomycota
Mycobacterium tuberculosis
วันที่เผยแพร่: 2012
บทคัดย่อ: Tuberculosis (TB) is one of the chronic infectious diseases caused by Mycobacterium tuberculosis that causes about 2-3 million deaths per year. Isoniazid and rifampicin are examples of first line drugs used for TB treatment; however, they are potentially hepatotoxic. More effective and safer drugs are urgently needed, especially from natural products. Basidiomycete mushrooms are known as important sources of pharmaceutically active metabolites including an anti-TB agent. In this work, the chemical constituents of the edible mushroom Astraeus odoratus were isolated and investigated for antibacterial activity against M. tuberculosis H37Ra. The cytotoxic activity against cancerous cell lines was also evaluated. Four new lanostane triterpenes, astraodoric acids A-D, and new 5-hydroxyhypaphorine have been isolated together with four known compounds. The structures were elucidated by NMR spectroscopic methods, HR-ESI-MS results, and X-ray crystallographic analysis. Astraodoric acids A and B exhibited moderate antibacterial (MICs of 50 and 25 μg/mL) and cytotoxic activities (IC50 values of 34.69 and 18.57 μg/mL against KB and 19.99 and 48.35 μg/mL against NCI-H187), respectively. The results of this study show that A. odoratus could be a significant natural source for safer antitubercular and anticancer agents. © 2012 American Chemical Society.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14263
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867075044&doi=10.1021%2fjf302433r&partnerID=40&md5=baade09c31240474ca2285d952d2a26d
ISSN: 218561
Appears in Collections:Scopus 1983-2021

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