Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14262
ชื่อเรื่อง: Larva migration and eosinophilia in mice experimentally infected with Gnathostoma spinigerum
ผู้แต่ง: Saksirisampant W.
Choomchuay N.
Kraivichian K.
Wongsatayanon Thanomsub B.
Keywords: animal experiment
animal model
animal tissue
article
body fat
controlled study
diaphragm
eosinophil
eosinophilia
esophagus
experimental infection
Gnathostoma spinigerum
gnathostomiasis
heart
histology
larval stage
liver
lung
male
mesentery
mouse
muscle
nonhuman
parasite migration
parasite virulence
stomach
Gnathostoma spinigerum
Mus
วันที่เผยแพร่: 2012
บทคัดย่อ: Background: Gnathostoma spinigerum causes larva migran in human which is endemic in Southeast Asia. Information regarding larva migration is limited. In this study, we investigated the parasite migration by recovery of worms from the whole body of mouse after oral infection with advanced third stage larvae (AL3). The percentage of blood eosinophils was examined in parallel. Methods: Mice were orally infected with AL3 and histological study of organs was investigated in order to study the migration of AL3, along with blood eosinophilia. Results: At 1 hr post infection (PI), the larvae remained in the stomach, thereafter at 3, 5, 7, 10 and 24 hr PI; they were recovered from various organs including liver, mesentery, esophagus, diaphragm, lung, heart and dorsal fat. At day 15 PI, they were mostly found in muscles (76.47%). The average worm recovery (5 months) was 78.03%. The worms were found in the liver at every time point. Larva encystment was detected. There was a significant difference in blood eosinophils between the 8 larvae (average 9.33% ± 6.25%) and the 15 larvae-infected groups (average 22.66% ± 11.03%). Surprisingly, the blood eosinophils (average 19.00% ± 2.92%) were not higher in the higher infective dose- group (25 larvae). Conclusion: Liver was involved by G. spinigerum throughout the study. We detected larva encystment which had never been reported in human gnathostomiasis. The highest percentage of eosinophil occurred during the invasive stage.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14262
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867017263&partnerID=40&md5=29be22a4800e9fd0cd8fd0867f4f4937
ISSN: 17357020
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.