Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14105
ชื่อเรื่อง: Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites
ผู้แต่ง: Chitchumroonchokchai C.
Thomas-Ahner J.M.
Li J.
Riedl K.M.
Nontakham J.
Suksumrarn S.
Clinton S.K.
Kinghorn A.D.
Failla M.L.
Keywords: antineoplastic agent
beta catenin
biological marker
mangostin
protein bcl 2
xanthone
xanthone derivative
animal
article
Bagg albino mouse
beverage
cell proliferation
cell strain HT29
cell survival
colon tumor
diet
drug effect
drug screening
female
genetics
human
metabolism
mouse
nude mouse
tissue distribution
Animals
Antineoplastic Agents
beta Catenin
Beverages
Biological Markers
Cell Proliferation
Cell Survival
Colonic Neoplasms
Diet
Female
HT29 Cells
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Proto-Oncogene Proteins c-bcl-2
Tissue Distribution
Xanthones
Xenograft Model Antitumor Assays
Garcinia mangostana
Mus
วันที่เผยแพร่: 2013
บทคัดย่อ: Scope: This study investigated the in vivo and in vitro activity of α-mangostin (α-MG), the most abundant xanthone in mangosteen pericarp, on HT-29 cell tumorigenicity, proliferation, and several markers of tumor cell activity, as well as the profile and amounts of xanthones in serum, tumor, liver, and feces. Methods and results: Balb/c nu/nu mice were fed either control diet or diet containing 900 mg α-MG/kg. After 1 week of acclimation to diet, mice were injected subcutaneously with HT-29 cells and fed the same diets ad libitum for an additional 2 or 4 weeks. After 2 and 4 weeks, tumor mass and the concentrations of BcL-2 and β-catenin in tumors of mice fed diet with α-MG were significantly less than in mice fed control diet. Xanthones and their metabolites were identified in serum, tumor, liver, and feces. In vitro treatment of HT-29 cells with α-MG also inhibited cell proliferation and decreased expression of BcL-2 and β-catenin. Conclusion: Our data demonstrate that the anti-neoplastic effect of dietary α-MG is associated with the presence of xanthones in the tumor tissue. Further investigation of the impact of beverages and food products containing xanthones on the prevention of colon cancer or as complementary therapy is merited. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14105
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872793155&doi=10.1002%2fmnfr.201200539&partnerID=40&md5=67081c477069e78a38e98c94ab48d398
ISSN: 16134125
Appears in Collections:Scopus 1983-2021

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