Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14079
ชื่อเรื่อง: α-Mangostin: Anti-inflammatory activity and metabolism by human cells
ผู้แต่ง: Gutierrez-Orozco F.
Chitchumroonchokchai C.
Lesinski G.B.
Suksamrarn S.
Failla M.L.
Keywords: Anti-inflammatory activity
Enhanced absorption
Human cell lines
Human cells
Human monocyte-derived macrophages
inflammation
mangosteen
xanthones
Biomolecules
Cell culture
Macrophages
Metabolism
Metabolites
Monolayers
Tissue
Physiology
Garcinia mangostana
dyes, reagents, indicators, markers and buffers
mangostin
nonsteroid antiinflammatory agent
protein kinase inhibitor
xanthone derivative
cell line
cell survival
chemistry
drug effects
Garcinia mangostana
human
inflammation
metabolism
Anti-Inflammatory Agents, Non-Steroidal
Cell Line
Cell Survival
Garcinia mangostana
Humans
Indicators and Reagents
Inflammation
Protein Kinase Inhibitors
Xanthones
วันที่เผยแพร่: 2013
บทคัดย่อ: Information about the anti-inflammatory activity and metabolism of α-mangostin (α-MG), the most abundant xanthone in mangosteen fruit, in human cells is limited. On the basis of available literature, we hypothesized that α-MG will inhibit the secretion of pro-inflammatory mediators by control and activated macrophage-like THP-1, hepatic HepG2, enterocyte-like Caco-2, and colon HT-29 human cell lines, as well as primary human monocyte-derived macrophages (MDM), and that such activity would be influenced by the extent of metabolism of the xanthone. α-MG attenuated TNF-α and IL-8 secretion by the various cell lines but increased TNF-α output by both quiescent and LPS-treated MDM. The relative amounts of free and phase II metabolites of α-MG and other xanthones present in media 24 h after addition of α-MG was shown to vary by cell type and inflammatory insult. Increased transport of xanthones and their metabolites across Caco-2 cell monolayers suggests enhanced absorption during an inflammatory episode. The anti-inflammatory activities of xanthones and their metabolites in different tissues merit consideration. © 2013 American Chemical Society.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14079
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876701750&doi=10.1021%2fjf4004434&partnerID=40&md5=effdaa34fb46606cdccf5f91ea42cda1
ISSN: 218561
Appears in Collections:Scopus 1983-2021

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