Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14051
ชื่อเรื่อง: Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice
ผู้แต่ง: Tripanichkul W.
Jaroensuppaperch E.-O.
Keywords: calcium binding protein
calcium binding protein iba1
copper zinc superoxide dismutase
curcumin
glial fibrillary acidic protein
oxidopamine
tyrosine 3 monooxygenase
unclassified drug
animal cell
animal experiment
animal model
animal tissue
article
astrocyte
controlled study
corpus striatum
denervation
dopaminergic activity
glia
immunohistochemistry
immunoreactivity
male
microglia
mouse
nonhuman
parkinsonism
protein expression
Animals
Anti-Inflammatory Agents
Corpus Striatum
Curcumin
Male
Mice
Mice, Inbred ICR
Neuroglia
Neuroprotective Agents
Oxidopamine
Parkinson Disease
Superoxide Dismutase
Tyrosine 3-Monooxygenase
วันที่เผยแพร่: 2013
บทคัดย่อ: BACKGROUND: Inflammation and oxidative stress are believed to contribute to neuronal degeneration of the nigrostriatal dopaminergic (DA) pathway in Parkinson's disease. Curcumin, a component of the yellow curry spice, has been reported possessing anti-inflammatory and anti-oxidative effects. AIM: The present study investigated the effects of curcumin on the extent of DA innervation, glial response, and Cu/Zn superoxide dismutase (SOD1) expression in the striatum of 6-hydroxydopamine (6-OHDA)-lesioned mice. MATERIALS AND METHODS: 6-OHDA was unilaterally injected into the right striatum of ICR male mice. Curcumin (200 mg/kg) was administered daily for 7 days starting instantaneously after 6-OHDA injection. Seven days after 6-OHDA insult, mice were euthanized and striatal sections were collected, immunohistochemically stained, and quantitated for tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule 1 (Iba1), and SOD1 immunoreactivity. RESULTS: 6-OHDA injection triggered a significant loss of TH-immunoreactive (-IR) axons, induced reaction of GFAP-IR astrocytes and Iba1-IR microglia, and decreased SOD1 expression in the 6-OHDA-lesioned striatum. Curcumin attenuated loss of TH-IR fibers, diminished activation of astrocytes and microglia, and sustained SOD1 level in the lesioned striatum. CONCLUSIONS: These results suggest that curcumin counteracts the neurotoxicity of 6-OHDA through its anti-inflammatory properties (inhibition of glial response) and preservation of SOD1 expression.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14051
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878621998&partnerID=40&md5=1bada10e62ad317e984be7ba49cd4a40
ISSN: 11283602
Appears in Collections:Scopus 1983-2021

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