Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13952
ชื่อเรื่อง: Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia
ผู้แต่ง: Sirachainan N.
Anurathapan U.
Chuansumrit A.
Songdej D.
Wongwerawattanakoon P.
Hutspardol S.
Kitpoka P.
Keywords: igamed
immunoglobulin
methotrexate
methylprednisolone
prednisolone
rhesus D antibody
unclassified drug
vincristine
alloantibody
RHO(D) antibody
adolescent
article
child
chronic immune thrombocytopenia
clinical article
disease severity
female
follow up
human
male
preschool child
priority journal
school child
thrombocyte count
thrombocytopenia
treatment response
intramuscular drug administration
Purpura, Thrombocytopenic, Idiopathic
severity of illness index
Adolescent
Child
Child, Preschool
Female
Humans
Injections, Intramuscular
Isoantibodies
Male
Purpura, Thrombocytopenic, Idiopathic
Severity of Illness Index
วันที่เผยแพร่: 2013
บทคัดย่อ: Nine patients with chronic immune thrombocytopenia and platelet counts <20 × 109/L, with a median age of 7.8 (3.8-15.5) years, received three phases of 10 mcg/kg/dose of intramuscular anti-D. Phase 1 was anti-D daily for 5 days, followed by phase 2, anti-D weekly for 12 weeks and withheld when platelet counts ≥20 × 109/L, and then phase 3 was anti-D once every 2 weeks for 24 weeks. According to the International Working Group criteria, in phase 1, 66.7% of patients responded to the treatment. In phases 2 and 3, 11.1% (0-41.7%) and 7.7% (0-33.3%) of total episodes of follow up, respectively, responded to the treatment. Therefore, intramuscular anti-D given at a dose of 10 mcg/kg for 5 days is an alternative method to raise platelet counts in chronic immune thrombocytopenia children with severe thrombocytopenia where the intravenous form of anti-D is not available. © 2013 Japan Pediatric Society.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13952
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84890443282&doi=10.1111%2fped.12179&partnerID=40&md5=3d3231196c2f483d54c9ab452bbe986e
ISSN: 13288067
Appears in Collections:Scopus 1983-2021

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