Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13932
ชื่อเรื่อง: Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice
ผู้แต่ง: Gutierrez-Orozco F.
Thomas-Ahner J.M.
Berman-Booty L.D.
Galley J.D.
Chitchumroonchokchai C.
Mace T.
Suksamrarn S.
Bailey M.T.
Clinton S.K.
Lesinski G.B.
Failla M.L.
Keywords: amyloid
dextran sulfate
interleukin 6
mangostin
peroxidase
xanthone derivative
animal
blood
C57BL mouse
chemically induced
chemistry
colon
diet
diet supplementation
disease model
drug effects
dysbiosis
enzymology
female
fruit
Garcinia mangostana
isolation and purification
metabolism
microbiology
mouse
pathology
Proteobacteria
ulcerative colitis
Amyloid
Animals
Colitis, Ulcerative
Colon
Dextran Sulfate
Diet
Dietary Supplements
Disease Models, Animal
Dysbiosis
Female
Fruit
Garcinia mangostana
Interleukin-6
Mice
Mice, Inbred C57BL
Peroxidase
Proteobacteria
Xanthones
วันที่เผยแพร่: 2014
บทคัดย่อ: Scope: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. α-Mangostin (α-MG), the most abundant xanthone in mangosteen fruit, exerts anti-inflammatory and antibacterial activities in vitro. We evaluated the impact of dietary α-MG on murine experimental colitis and on the gut microbiota of healthy mice. Methods and results: Colitis was induced in C57BL/6J mice by administration of dextran sulfate sodium (DSS). Mice were fed control diet or diet with α-MG (0.1%). α-MG exacerbated the pathology of DSS-induced colitis. Mice fed diet with α-MG had greater colonic inflammation and injury, as well as greater infiltration of CD3+ and F4/80+ cells, and colonic myeloperoxidase, than controls. Serum levels of granulocyte colony-stimulating factor, IL-6, and serum amyloid A were also greater in α-MG-fed animals than in controls. The colonic and cecal microbiota of healthy mice fed α-MG but no DSS shifted to an increased abundance of Proteobacteria and decreased abundance of Firmicutes and Bacteroidetes, a profile similar to that found in human UC. Conclusion: α-MG exacerbated colonic pathology during DSS-induced colitis. These effects may be associated with an induction of intestinal dysbiosis by α-MG. Our results suggest that the use of α-MG-containing supplements by patients with UC may have unintentional risk. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13932
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901947811&doi=10.1002%2fmnfr.201300771&partnerID=40&md5=9e7ce980cf2d7c2bef7901d487535534
ISSN: 16134125
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.