Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13740
ชื่อเรื่อง: Vascular endothelial growth factor-C expression as a biomarker of poor prognosis in esophageal squamous cell carcinoma: a meta-analysis
ผู้แต่ง: Tullavardhana T.
Akranurakkul P.
Ungkitphaiboon W.
Songtish D.
Keywords: messenger RNA
tumor marker
vasculotropin C
VEGFC protein, human
VEGFC protein, human
VEGFC protein, human
Carcinoma, Squamous Cell
Esophageal Neoplasms
gene expression regulation
genetics
human
immunohistochemistry
lymph node metastasis
meta analysis
metabolism
mortality
physiology
polymerase chain reaction
prognosis
survival rate
Biomarkers, Tumor
Biomarkers, Tumor
Biomarkers, Tumor
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell
Esophageal Neoplasms
Esophageal Neoplasms
Esophageal Neoplasms
Gene Expression Regulation, Neoplastic
Gene Expression Regulation, Neoplastic
Gene Expression Regulation, Neoplastic
Humans
Humans
Humans
Immunohistochemistry
Immunohistochemistry
Immunohistochemistry
Lymphatic Metastasis
Lymphatic Metastasis
Lymphatic Metastasis
Polymerase Chain Reaction
Polymerase Chain Reaction
Polymerase Chain Reaction
Prognosis
Prognosis
Prognosis
RNA, Messenger
RNA, Messenger
RNA, Messenger
Survival Rate
Survival Rate
Survival Rate
Vascular Endothelial Growth Factor C
Vascular Endothelial Growth Factor C
Vascular Endothelial Growth Factor C
วันที่เผยแพร่: 2015
บทคัดย่อ: BACKGROUND: Vascular endothelial growth factor C (VEGF-C) is involved in the development and progression of tumor angio-/lymphangiogenesis. The purpose of this study is to evaluate whether VEGF-C expression is an indicator of aggressiveness and poor prognosis of esophageal squamous cell carcinoma (ESCC).METHOD: A meta-analysis was conducted to investigate the association between VEGF-C expression with clinicopathological characteristics and survival of ESCC patients. The dataset was defined by searching PubMed, Embase, Google Scholar, and the Cochrane database for appropriate articles published until April 2014.RESULT: The final analysis was made from 9 studies, including 656 ESCC patients. Positive VEGF-C expression was defined by immunohistochemistry (IHC) or mRNA expression analysis. The results demonstrated that VEGF-C expression was significantly associated with advanced-stage disease (odds ratio (OR) = 2.29, 95% confidence interval (CI) = 1.37-3.84, P = 0.002), deeper tumor invasion, lymph node metastasis, and lymphatic invasion. The 5-year survival of VEGF-C expression-negative patients was found to be better than that of VEGF-C expression-positive patients (OR = 0.35, 95% CI = 0.21-0.58, P < 0.0001). However, there was no significant association between the VEGF-C expression levels and either poorer tumor differentiation or vascular invasion.CONCLUSION: The results of the meta-analysis strongly indicate that VEGF-C expression could function as a marker for predicting the aggressiveness and prognosis of ESCC. © 2015 S. Karger GmbH, Freiburg.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13740
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941046316&doi=10.1159%2f000380776&partnerID=40&md5=1dd86bef5a99fa0fb3d43673fa18e22e
ISSN: 22965262
Appears in Collections:Scopus 1983-2021

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