Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13697
ชื่อเรื่อง: One base pair deletion and high rate of evolution: Keys to viral accommodation of Australian Penaeus stylirostris densovirus
ผู้แต่ง: Jaroenram W.
Chaivisuthangkura P.
Owens L.
Keywords: enzyme activity
evolution
genetic variation
mutation
shrimp fishery
viral disease
virulence
Australia
Indian Ocean
Pacific Ocean
Decapoda (Crustacea)
Densovirus
Infectious hypodermal and hematopoietic necrosis virus
Litopenaeus stylirostris
วันที่เผยแพร่: 2015
บทคัดย่อ: Penaeus stylirostris densovirus (PstDV) has caused large economic losses to shrimp farming worldwide. Here, a 1-bp deletion within the nuclear localization signal-encoding sequence of open reading frame 1 (ORF1; NS1) of Australian PstDV was identified as a cause of 199-amino acid shortened NS1 protein and production of a second protein, C-terminal NS1. This mutation is believed to reduce virulence as it strongly modifies the characteristics of NS1, which is responsible for the majority of enzymatic activities in PstDV. This finding supports a hypothesis regarding accommodation of PstDV in Australian prawns in relation to viral genetics. However, a high degree of evolution (1.55×10-3 substitutions/site/year) and genetic variation for the virus was attributable to the viral recombination observed with 10 potential genomic breakpoints identified. With this finding, we suggest that awareness of the emergence of new virulent strains should be increased as a preventative measure against future outbreaks of PstDV in the Australian Indo-Pacific. © 2015 Elsevier B.V.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13697
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925832877&doi=10.1016%2fj.aquaculture.2015.03.003&partnerID=40&md5=5b5261d009c0bcab00d54216225d4e6f
ISSN: 448486
Appears in Collections:Scopus 1983-2021

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