Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13485
ชื่อเรื่อง: Surface modification of poly(D,L-lactic-co-glycolic acid) nanoparticles using sodium carboxymethyl cellulose as colloidal stabilizer
ผู้แต่ง: Chittasupho C.
Thongnopkoon T.
Kewsuwan P.
Keywords: carboxymethylcellulose
doxorubicin
nanoparticle
polyglactin
stabilizing agent
carboxymethylcellulose
drug carrier
excipient
lactic acid
nanoparticle
polyglycolic acid
polylactic acid-polyglycolic acid copolymer
adsorption
Article
cell viability
colloid
colorimetry
controlled study
differential scanning calorimetry
dispersion
human
human cell
infrared spectroscopy
particle size
priority journal
surface property
zeta potential
A-549 cell line
cell survival
chemistry
drug delivery system
drug effects
drug stability
procedures
tumor cell line
A549 Cells
Adsorption
Carboxymethylcellulose Sodium
Cell Line, Tumor
Cell Survival
Drug Carriers
Drug Delivery Systems
Drug Stability
Excipients
Humans
Lactic Acid
Nanoparticles
Particle Size
Polyglycolic Acid
วันที่เผยแพร่: 2016
บทคัดย่อ: Poly(D,L-lactic-co-glycolic acid) nanoparticles (PLGA NPs) have been widely used as drug delivery systems for both small molecules and macromolecules. However, the colloidal stability problem remains unsolved. This study aims to investigate the possibility of using sodium carboxymethyl cellulose (SCMC) as a stabilizing agent of PLGA NPs. In this study, PLGA NPs were fabricated using various concentrations of SCMC (0.01, 0.1 and 0.5% w/v) by solvent displacement method. SCMC coated NPs were characterized using DLS, FTIR, DSC, colorimetric method. Particle size, polydispersity index, zeta potential values and SCMC adsorption increased with SCMC concentration. FTIR spectra, DSC thermograms and results of colorimetry suggested the interaction of SCMC and PLGA NPs. The stability of SCMC coated PLGA NPs was observed during the storage of three weeks in water. The stability of SCMC coated NPs in serum was also evaluated. Cell viability study revealed that there was no toxicity increased when SCMC was used as a stabilizing agent up to a concentration of 0.1% w/v. SCMC coated PLGA NPs bound A549 cells in a time dependent manner and with a greater extent than uncoated PLGA NPs. In conclusion, SCMC can be used to stabilize PLGA NPs by adsorbing on the surface of NPs. © 2016 Bentham Science Publishers.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13485
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964076400&doi=10.2174%2f1567201812666150904144241&partnerID=40&md5=30c90d3f81f4ae94fe389ef425ecb8af
ISSN: 15672018
Appears in Collections:Scopus 1983-2021

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