Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13466
Title: Predictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition–Associated Cholestasis in Premature Infants With Intestinal Perforation
Authors: Vongbhavit K.
Underwood M.A.
Keywords: alanine aminotransferase
aspartate aminotransferase
bilirubin
alanine aminotransferase
aspartate aminotransferase
bilirubin
alanine aminotransferase level
Apgar score
Article
aspartate aminotransferase level
aspartate aminotransferase to platelet ratio index
bilirubin blood level
birth weight
bloodstream infection
cholestasis
clinical outcome
cohort analysis
controlled study
diagnostic test accuracy study
disease severity
enteric feeding
female
gestational age
hospitalization
human
intestine function
intestine perforation
length of stay
liver function test
major clinical study
male
medical record
metabolism parameters
necrotizing enterocolitis
parenteral nutrition
predictive value
prematurity
priority journal
retrospective study
risk factor
sensitivity and specificity
small for date infant
adverse event
blood
cholestasis
intestine perforation
liver
liver disease
metabolism
newborn
newborn disease
parenteral nutrition
pathology
prematurity
sepsis
thrombocyte
very low birth weight
Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
Birth Weight
Blood Platelets
Cholestasis
Female
Gestational Age
Humans
Infant, Newborn
Infant, Newborn, Diseases
Infant, Premature
Infant, Very Low Birth Weight
Intestinal Perforation
Liver
Liver Diseases
Liver Function Tests
Male
Parenteral Nutrition
Risk Factors
Sepsis
Issue Date: 2018
Abstract: Background: Parenteral nutrition–associated cholestasis (PNAC) is a major cause of morbidity and mortality in premature infants. Early predictors of PNAC would have clinical value. We sought to evaluate risk factors and liver function testing as predictors of PNAC in premature infants with intestinal perforation. Methods: Medical records of infants with a gestational age <34 weeks, birth weight <2000 g, and intestinal perforation due to either necrotizing enterocolitis or spontaneous intestinal perforation were reviewed. We analyzed clinical data and the maximum values of the aspartate aminotransferase (AST) to platelet ratio index (APRI), alanine aminotransferase (ALT), AST to ALT ratio, and total bilirubin (TB). Results: Sixty infants were identified, 17 infants with PNAC and 43 infants without PNAC. Sepsis, time to initiation of enteral feeds after perforation, and duration of PN were associated with PNAC. Within 2 weeks following intestinal perforation, APRI, ALT, and TB each differed significantly between infants who later developed PNAC and those that did not. The best APRI cut-point was 0.4775 within 2 weeks after perforation (area under the receiver operating characteristic curve, 0.90; positive predictive value, 85%; and negative predictive value, 87%); the cut-point for ALT was 13.5 (0.90, 85%, 84%), and the cut-point for TB was 3.55 (0.82, 69%, 83%), respectively, at 2 weeks after perforation. AST to ALT ratio did not differ between groups. Conclusions: APRI and ALT had reasonable predictive value for PNAC in premature infants with intestinal perforation, with the APRI the best predictor within 2 weeks after perforation. © 2017 American Society for Parenteral and Enteral Nutrition
URI: https://ir.swu.ac.th/jspui/handle/123456789/13466
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045892482&doi=10.1177%2f0148607117722755&partnerID=40&md5=7cce65bcad7f26a68bb3ad5a4ab5aee5
ISSN: 1486071
Appears in Collections:Scopus 1983-2021

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