Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13436
ชื่อเรื่อง: Lack of associations between TNF-α polymorphisms and cervical cancer in Thai women
ผู้แต่ง: Chinchai T.
Homchan K.
Sopipong W.
Chansaenroj J.
Swangvaree S.
Junyangdikul P.
Vongpunsawad S.
Poovorawan Y.
Keywords: tumor necrosis factor
adult
aged
case control study
female
genetic predisposition
genetics
genotype
human
middle aged
Papillomaviridae
pathogenicity
promoter region
risk factor
single nucleotide polymorphism
Thailand
uterine cervix tumor
very elderly
virology
young adult
Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Middle Aged
Papillomaviridae
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Risk Factors
Thailand
Tumor Necrosis Factor-alpha
Uterine Cervical Neoplasms
Young Adult
วันที่เผยแพร่: 2016
บทคัดย่อ: The risk of developing cervical cancer in women infected with human papillomavirus (HPV) may be influenced by an individual's genetic susceptibility. Published data linking single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-α) promoter region at positions-308G > A (rs1800629) and -238G > A (rs361525) to cervical cancer risk have been inconclusive. In this study, we examined 251 cervical specimens and classified them into two groups according to their cytological findings: 121 cancer cases and 130 controls (low-grade squamous intraepithelial lesion and normal cytology). All specimens were typed by PCR and sequencing for TNF-α promoter-308G > A (rs1800629) and -238G > A (rs361525). The genotype distribution of SNPs in either rs1800629 or rs361525 did not significantly demonstrate higher frequency in the cancer group (p=0.621 and p=0.68, respectively). Based on these results, neither the TNF-α promoter-308G > A (rs1800629) nor the -238G > A (rs361525) polymorphism presents a major risk factor for cervical cancer among Thai women. Larger studies are necessary to elucidate possible genetic mechanisms influencing cervical cancer development.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13436
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84965079449&doi=10.7314%2fAPJCP.2016.17.3.953&partnerID=40&md5=92d41fedfcc86847453b7d39100b3572
ISSN: 15137368
Appears in Collections:Scopus 1983-2021

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