Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13272
ชื่อเรื่อง: Unexpected synthesis of 3-imino-2-(pyrrol-2-yl) isatogen derivatives affords facile access to a 2-pyrrolyl isatogen
ผู้แต่ง: Kirk N.S.
Sansom G.N.
Sudta P.
Suksamrarn S.
Willis A.C.
Bremner J.B.
Kelso M.J.
Keywords: amide
antiprotozoal agent
imine
isatogen derivative
unclassified drug
antiprotozoal activity
Article
crystal structure
drug synthesis
hydrogen bond
hydrolysis
in vitro study
nonhuman
Plasmodium falciparum
วันที่เผยแพร่: 2017
บทคัดย่อ: 2-Aryl isatogens and their 3-imino derivatives have been extensively studied but to date there have been no reported variants carrying pyrrolyl substituents at the 2-position. This study describes the unexpected synthesis of two novel 3-imino-2-(pyrrol-2-yl) isatogen derivatives upon attempted amide couplings with (E)- or (Z)-3-(3,5-dimethyl-1H-pyrrol-2-yl)-2-(2-nitrophenyl)acrylic acids and p-phenylenediamines in the presence of uronium-based coupling reagents. Imine hydrolysis of one derivative under mild acid conditions afforded a 2-pyrrolyl isatogen in high yield. The compound showed potent in vitro antiplasmodial activity against Plasmodium falciparum. © 2017, Copyright © Taylor & Francis Group, LLC.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13272
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85001022754&doi=10.1080%2f00397911.2016.1249290&partnerID=40&md5=7949854671a017e164167bc9082ccf60
ISSN: 397911
Appears in Collections:Scopus 1983-2021

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