Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13230
ชื่อเรื่อง: Restoration of lung microvasculature in diabetic condition after curcumin supplementation
ผู้แต่ง: Anupunpisit V.
Petpiboolthai H.
Khanpetch P.
Pramong R.
Keywords: bone morphogenetic protein receptor 2
curcumin
animal experiment
animal model
Article
controlled study
corrosion casting
diabetes mellitus
lung arteriole
lung arteriole shrinkage
lung arteriole shrinkage
lung blood vessel
lung capillary
lung capillary deformity
lung capillary deformity
lung capillary shrinkage
lung capillary shrinkage
lung circulation
lung disease
male
microangiopathy
microvasculature
nonhuman
rat
scanning electron microscopy
streptozotocin-induced diabetes mellitus
supplementation
วันที่เผยแพร่: 2017
บทคัดย่อ: Objective: To investigate the effect of curcumin in the restoration of lung microvasculature in streptozotocin-induced diabetic model. Material and Method: Operation of diabetic rat model was induced by streptozotocin (STZ: 60 mg/kg BW). Male rats (7 to 8 weeks old) have been classified into three groups, control (C), diabetic (DM) and diabetic rats supplemented with curcumin (DMC) (200 mg/kg BW). After 8 weeks, lung microvasculature was investigated under vascular corrosion cast technique and examined by scanning electron microscope (SEM). Results: In DM group, structural damages of pulmonary capillary level were obviously severe, defined as microangiopathy. The predominant abnormality of pulmonary capillary revealed destroyed characteristics such as shrinkage, constriction and capillary bed deformity. Furthermore, some destruction was observed at arteriole level whereas destructions of large and small arteries were rarely noticed. Regarding the diameters, the pulmonary capillary of DM group considerably decreased in sizes. Interestingly, upon curcumin supplementation, recovery of pulmonary capillary was predominantly enhanced, demonstrating reformed typical microvasculature pattern. Moreover, the diameter sizes of DMC pulmonary capillary were fully restored forward to normal control condition. Conclusion: Curcumin in diabetic rat could appreciably restored pulmonary microangiopathy at pulmonary capillary toward normal structure. Curcumin might be a novel therapeutic agent in pulmonary microvascular diabetic complications. © 2017 Medical Association of Thailand. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13230
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075006742&partnerID=40&md5=4c13d192ce8434f5d29e4d20a0f33ae4
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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