Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13138
ชื่อเรื่อง: Secondary metabolites from the marine-derived fungus dichotomomyces sp. L-8 and their cytotoxic activity
ผู้แต่ง: Huang L.-H.
Chen Y.-X.
Yu J.-C.
Yuan J.
Li H.-J.
Ma W.-Z.
Watanapokasin R.
Hu K.-C.
Niaz S.I.
Yang D.-P.
Lan W.-J.
Keywords: antineoplastic agent
bis-N-norgliovictin
lateritin
morpholine derivative
piperazinedione
sulfide
aquatic species
budding yeast
cell survival
chemical structure
chemistry
drug effects
human
IC50
isolation and purification
metabolism
nuclear magnetic resonance spectroscopy
physiology
secondary metabolism
structure activity relation
tumor cell line
Antineoplastic Agents, Phytogenic
Aquatic Organisms
Cell Line, Tumor
Cell Survival
Diketopiperazines
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Morpholines
Saccharomycetales
Secondary Metabolism
Structure-Activity Relationship
Sulfides
วันที่เผยแพร่: 2017
บทคัดย่อ: Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC50 values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13138
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015695560&doi=10.3390%2fmolecules22030444&partnerID=40&md5=90dba95d7b9c5a6b0ca287cfab1042f7
ISSN: 14203049
Appears in Collections:Scopus 1983-2021

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